Evidence map›Paper›PMID 40001558›Full record

ArticleBiomolecules2025

Diagnosis and Staging of Metabolic Dysfunction-Associated Steatotic Liver Disease Using Biomarker-Directed Aptamer Panels.

Mikkel B Kjær, Asger G Jørgensen, Søren Fjelstrup, Daniel M Dupont, Claus Bus, Peter L Eriksen, Karen L Thomsen, Jeyanthini Risikesan, Søren Nielsen, Charlotte W Wernberg and 5 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mikkel B KjærDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.ORCID 0000-0002-6385-5108
Asger G JørgensenInterdisciplinary Nanoscience Centre (iNANO), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.ORCID 0000-0002-5347-0685
Søren FjelstrupInterdisciplinary Nanoscience Centre (iNANO), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
Daniel M DupontInterdisciplinary Nanoscience Centre (iNANO), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.ORCID 0000-0003-1378-1670
Claus BusInterdisciplinary Nanoscience Centre (iNANO), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.ORCID 0000-0002-7706-1456
Peter L EriksenDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.ORCID 0000-0003-1115-8308
Karen L ThomsenDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.ORCID 0000-0002-8118-4643
Jeyanthini RisikesanSteno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.ORCID 0000-0002-4195-6231
Søren NielsenSteno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard 11, 8200 Aarhus N, Denmark.ORCID 0000-0002-8624-5556
Charlotte W WernbergDepartment of Gastroenterology and Hepatology, University Hospital of Southern Denmark, 6700 Esbjerg, Denmark.ORCID 0000-0001-8964-0650
Mette M LauridsenDepartment of Gastroenterology and Hepatology, University Hospital of Southern Denmark, 6700 Esbjerg, Denmark.ORCID 0000-0003-0586-8549
Elisabetta BugianesiDepartment of Medical Sciences, University of Turin, Via Verdi 8, 10124 Torino, Italy.ORCID 0000-0002-0502-4381
Chiara RossoDepartment of Medical Sciences, University of Turin, Via Verdi 8, 10124 Torino, Italy.ORCID 0000-0001-6518-7089
Henning GrønbækDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.ORCID 0000-0001-8998-7910
Jørgen KjemsInterdisciplinary Nanoscience Centre (iNANO), Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.ORCID 0000-0003-4128-9317

Funding

Novo Nordisk Foundation NNF20SA0061466Steno Diabetes Center Partially funded by an unrestricted donation from the Novo Nordisk Foundation
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects one-third of adults globally. Despite efforts to develop non-invasive diagnostic tools, liver biopsy remains the gold standard for diagnosing metabolic dysfunction-associated steatohepatitis (MASH) and assessing fibrosis. This study investigated RNA aptamer panels, selected using APTASHAPE technology, for non-invasive MASLD diagnosis and fibrosis stratification. Aptamer panels were selected in a cohort of individuals with MASLD (development cohort,

Indexed as

Aptamers, NucleotideFatty LiverNon-alcoholic Fatty Liver DiseaseAdultBiomarkersFemaleHumansLiver CirrhosisMaleMiddle AgedSELEX Aptamer TechniqueAptamers, NucleotideBiomarkersaptamerbiomarkermetabolic dysfunction-associated steatohepatitismetabolic dysfunction-associated steatotic liver disease

Identifiers

PMID40001558
PMCPMC11852711

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.