Evidence map›Paper›PMID 40001538›Full record

ArticleBiomolecules2025

Differential Expression of miR-223-3p and miR-26-5p According to Different Stages of Mastitis in Dairy Cows.

Eleonora Dall'Olio, Fabio De Rensis, Eugenio Martignani, Silvia Miretti, Ugo Ala, Valeria Cavalli, Claudio Cipolat-Gotet, Melania Andrani, Mario Baratta, Roberta Saleri

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eleonora Dall'OlioDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.ORCID 0000-0001-6798-5834
Fabio De RensisDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.
Eugenio MartignaniDepartment of Veterinary Sciences, University of Torino, Largo Paolo Braccini 2, 10095 Grugliasco, Italy.ORCID 0000-0001-7748-1832
Silvia MirettiDepartment of Veterinary Sciences, University of Torino, Largo Paolo Braccini 2, 10095 Grugliasco, Italy.ORCID 0000-0002-6693-2527
Ugo AlaDepartment of Veterinary Sciences, University of Torino, Largo Paolo Braccini 2, 10095 Grugliasco, Italy.ORCID 0000-0001-5408-6397
Valeria CavalliDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.
Claudio Cipolat-GotetDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.ORCID 0000-0002-2318-4231
Melania AndraniDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.ORCID 0000-0003-3411-6135
Mario BarattaDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11a, 43124 Parma, Italy.ORCID 0000-0003-2537-6429
Roberta SaleriDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mastitis is the leading cause of economic losses in dairy farming, significantly impairing animal welfare and the quality and quantity of milk production. MicroRNAs are increasingly gaining attention, in both human and veterinary medicine, as biomarkers for various diseases. This study evaluated the diagnostic potential of four circulating microRNAs (miR-26-5p, miR-142-5p, miR-146a, and miR-223-3p) by examining changes in their expression in milk samples from dairy cows at different immune-cell subpopulations correlated to different stage of mastitis with a validated method. Additionally, this study has analyzed the possible source of these circulating microRNAs by the measurement of their secretion from activated immune cells (lymphocytes, monocytes, and neutrophils). miR-223-3p has been significantly expressed in an acute stage of mastitis (

Indexed as

Mastitis, BovineMicroRNAsAnimalsBiomarkersCattleFemaleGene Expression RegulationMilkNeutrophilsBiomarkersMicroRNAsbiomarkersdairy cowsdifferential somatic cell countmastitismiR-223miR-26

Identifiers

PMID40001538
PMCPMC11853211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.