Evidence map›Paper›PMID 40001529›Full record

ReviewBiomolecules2025

Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders.

Chisom J Onu, Michael Adu, Mohamed Chakkour, Vikalp Kumar, Miriam L Greenberg

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chisom J OnuDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Michael AduDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Mohamed ChakkourDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Vikalp KumarDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.ORCID 0009-0007-5136-1315
Miriam L GreenbergDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.

Funding

Regulation of Inositol Biosynthesis and Consequences of Inositol DepletionR35GM149271 · NIGMS · WAYNE STATE UNIVERSITY · PI Miriam L Greenberg · 2023 to 2026
$1.6M
Novel Mechanisms of Regulation of Inositol BiosynthesisR01GM125082 · NIGMS · WAYNE STATE UNIVERSITY · PI GREENBERG, MIRIAM L · 2017 to 2020
$1.5M
NIGMS NIH HHS R01 GM125082NIGMS NIH HHS R35 GM149271NIH HHS GM125082NIH HHS GM149271
6 · The paper itself

Abstract

Inositol is a vital sugar molecule involved in numerous signaling pathways required for cellular homeostasis and cell survival. Myo-inositol and its phospho-derivatives, inositol phosphates (IPs), are the most prevalent forms of inositol found in living cells. They are involved in regulating ion channels, metabolic flux, stress response, and other key biological processes. While emerging research has highlighted the significant roles of inositol phosphates in immunity, cancer, and metabolic diseases, there is a lack of comprehensive reviews on their roles in psychiatric and neurological disorders. This review aims to fill that gap by analyzing the existing literature on the importance of inositol phosphates in severe psychiatric and neurological conditions such as Parkinson's disease, Alzheimer's disease, bipolar disorder, amyotrophic lateral sclerosis, schizophrenia, and Huntington's disease, underscoring the potential to pave the way for new treatment regimens for these debilitating disorders targeting inositol pathways.

Indexed as

Inositol PhosphatesNeurodegenerative DiseasesAnimalsHumansInositolSignal TransductionInositolInositol Phosphatesinositolinositol phosphatesinositol pyrophosphatesneurodegenerativepsychiatric

Identifiers

PMID40001529
PMCPMC11853280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.