Evidence map›Paper›PMID 40001474›Full record

ArticleBiomolecules2025

Chikungunya Particle and RNA Induce Mechanical and Heat Hypersensitivities in a TRPV1-Dependent Manner.

Liziane C M da Silva, Andressa C Dos Santos Maia, Nágila C F de Sousa, Catielen P Pavi, Beatriz P Savi, Seigo Nagashima, Samara Damasceno, Ayda H Schneider, Lucas Z Mascarin, João F S Rodrigues and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Transient receptor potential channels inChannels (Austin, Tex.) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Liziane C M da SilvaPrograma de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.ORCID 0000-0002-6079-7280
Andressa C Dos Santos MaiaPrograma de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.ORCID 0000-0003-4010-8473
Nágila C F de SousaPrograma de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
Catielen P PaviDepartamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.ORCID 0000-0003-2506-3772
Beatriz P SaviDepartamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.
Seigo NagashimaEscola de Medicina e Ciências da Vida, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, PR, Brazil.
Samara DamascenoFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Ayda H SchneiderFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
Lucas Z MascarinDepartamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.
João F S RodriguesPrograma de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil.
Cinara R A V MonteiroPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 65085-040, MA, Brazil.
Izabella T SilvaDepartamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.ORCID 0000-0002-1893-4317
Gislaine FongaroDepartamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.ORCID 0000-0001-5596-3320
Valério Monteiro-NetoPrograma de Pós-Graduação em Ciências da Saúde, Universidade Federal do Maranhão, São Luís 65085-040, MA, Brazil.ORCID 0000-0003-2868-1314
Maria R Q BomfimPrograma de Pós-Graduação, Universidade CEUMA, São Luís 65075-120, MA, Brazil.ORCID 0000-0001-5738-3952
Thiago M CunhaFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14049-900, SP, Brazil.
João de Sousa ValenteThe School of Cardiovascular and Metabolic Medicine (South Bank), King's College London, London SE1 9NH, UK.
João B CalixtoCentro de Inovação e Ensaios Pré-Clínicos, Florianópolis 88056-000, SC, Brazil.ORCID 0000-0003-4041-7153
Lúcia de NoronhaEscola de Medicina e Ciências da Vida, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, PR, Brazil.ORCID 0000-0003-0310-7164
Susan D BrainThe School of Cardiovascular and Metabolic Medicine (South Bank), King's College London, London SE1 9NH, UK.ORCID 0000-0002-9684-8342
Elizabeth S FernandesPrograma de Pós-Graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente, Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.ORCID 0000-0002-0567-2514

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq grant numbers: 408053/2018-6 and 309098/2023-8 to E.S.F., and 317186/2023-0 to V.M.-N.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES finance code 001INCT - INOVAMED 00Instituto de Pesquisa Pelé Pequeno Príncipe - IPPPP 00
6 · The paper itself

Abstract

Chikungunya virus (CHIKV), the causative agent of the chikungunya fever, is an alphavirus widely transmitted by the bite of the female mosquito of the genus

Indexed as

Chikungunya virusHypersensitivityVirionAnimalsChikungunya FeverFemaleHot TemperatureHumansKnee JointMaleMembrane Transport ModulatorsMiceMice, Inbred C57BLNociceptionRNA, ViralTRPV Cation ChannelsMembrane Transport ModulatorsRNA, ViralTRPV1 protein, mouseTRPV Cation ChannelsarthralgiaChikungunyanociceptionTRPV1viral RNA

Identifiers

PMID40001474
PMCPMC11853433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.