Evidence map›Paper›PMID 40001460›Full record

ArticleBiomolecules2025

Biophysical Properties of Somatic Cancer Mutations in the S4 Transmembrane Segment of the Human Voltage-Gated Proton Channel hH

Christophe Jardin, Christian Derst, Arne Franzen, Iryna Mahorivska, Thomas E DeCoursey, Boris Musset, Gustavo Chaves

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Similarity of the ion occupations of KChannels (Austin, Tex.) · 2026
    Article
  2. Review
  3. Modulators of the Human Voltage-Gated Proton Channel HPharmaceuticals (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christophe JardinCenter of Physiology, Pathophysiology and Biophysics-Nuremberg, Paracelsus Medical University, 90419 Nuremberg, Germany.ORCID 0000-0003-1627-6960
Christian DerstCenter of Physiology, Pathophysiology and Biophysics-Nuremberg, Paracelsus Medical University, 90419 Nuremberg, Germany.
Arne FranzenInstitut für Biologische Informationsprozesse, Molekular-und Zellphysiologie (IBI-1), Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0002-8731-674X
Iryna MahorivskaCenter of Physiology, Pathophysiology and Biophysics-Nuremberg, Paracelsus Medical University, 90419 Nuremberg, Germany.
Thomas E DeCourseyDepartment of Physiology & Biophysics, Rush University, Chicago, IL 60612, USA.ORCID 0000-0002-4263-180X
Boris MussetCenter of Physiology, Pathophysiology and Biophysics-Nuremberg, Paracelsus Medical University, 90419 Nuremberg, Germany.ORCID 0000-0001-8242-8817
Gustavo ChavesCenter of Physiology, Pathophysiology and Biophysics-Nuremberg, Paracelsus Medical University, 90419 Nuremberg, Germany.ORCID 0000-0003-2599-8885

Funding

Control Mechanisms of Human Voltage Gated Proton Channels, hHv1R35GM151963 · NIGMS · RUSH UNIVERSITY MEDICAL CENTER · PI THOMAS E DECOURSEY · 2024 to 2026
$1.3M
Kerscher Stiftung FMS_FP_068.22-KNMSNIGMS NIH HHS R35 GM151963NIH HHS GM151963
6 · The paper itself

Abstract

Somatic mutations are common in cancer, with only a few driving the progression of the disease, while most are silent passengers. Some mutations may hinder or even reverse cancer progression. The voltage-gated proton channel (H

Indexed as

Ion ChannelsMutationNeoplasmsHumansHydrogen-Ion ConcentrationMolecular Dynamics SimulationMutation, MissenseProtonsHVCN1 protein, humanIon ChannelsProtonscancerhHV1pH-homeostasisS4 transmembrane domainsomatic mutationstumor cellsvoltage-gated proton channelsvoltage-sensing arginines

Identifiers

PMID40001460
PMCPMC11853527

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.