ArticleBiomolecules2025
A Genetic and Environmental Analysis of Inflammatory Factors in Chronic Widespread Pain Using the TwinsUK Cohort.
Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Modeling the genomic architecture of adiposity and anthropometrics across the lifespan.Nature communications · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
Chronic widespread musculoskeletal pain (CWP), a significant health issue affecting individuals and society, is often diagnosed as part of fibromyalgia but is not generally considered inflammatory. This study investigated the relationship between blood-based inflammatory factors and CWP in 904 individuals from the TwinsUK cohort. Participants, free of major inflammatory conditions, completed questionnaires to assess CWP. Plasma samples were analysed using the Olink panel, alongside assays for C-reactive protein (CRP) and Apolipoproteins A1 and B. No significant associations were observed between CWP and inflammatory factors after adjusting for multiple testing. Twin modelling revealed significant heritability for both CWP and inflammatory factors, with genetic covariance observed between CWP and several inflammatory factors. Additive Bayesian network modelling suggested that any association between CWP and inflammatory factors is mediated by body mass index (BMI). These findings emphasize the complexity of CWP and its potential reliance on factors beyond inflammation, such as BMI, which strongly correlates with CRP and other inflammatory markers. Future research should explore additional molecular, genetic, and environmental contributors to CWP variability and investigate clinical factors or covariates that may obscure relationships with inflammation, providing a more comprehensive understanding of this multifaceted condition.
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Registered trials
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