Evidence map›Paper›PMID 40001422›Full record

ArticleAntibiotics (Basel, Switzerland)2025

Exploring Antimycobacterial Potential: Safety Evaluation and Active Compound Isolation from

Jenske Didloff, Gerhardt J Boukes, Mutenta N Nyambe, Denzil R Beukes, Mookho S Lerata, Velile Vilane, Michael Lee, Sharlene Govender, Maryna van de Venter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenske DidloffDepartment of Biochemistry and Microbiology, Nelson Mandela University, P.O. Box 77000, Gqeberha 6031, South Africa.ORCID 0000-0001-7453-8119
Gerhardt J BoukesDepartment of Biochemistry and Microbiology, Nelson Mandela University, P.O. Box 77000, Gqeberha 6031, South Africa.
Mutenta N NyambeDepartment of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Nutrition and Dietetics, Lusaka Apex Medical University, Lusaka 10101, Zambia.
Denzil R BeukesSchool of Pharmacy, University of Western Cape, Bellville 7535, South Africa.ORCID 0000-0002-0223-2660
Mookho S LerataSchool of Pharmacy, University of Western Cape, Bellville 7535, South Africa.
Velile VilaneCenter for High-Resolution Transmission Electron Microscopy (HRTEM), Physics Department, Nelson Mandela University, P.O. Box 77000, Gqeberha 6031, South Africa.ORCID 0000-0002-9013-5579
Michael LeeCenter for High-Resolution Transmission Electron Microscopy (HRTEM), Physics Department, Nelson Mandela University, P.O. Box 77000, Gqeberha 6031, South Africa.ORCID 0000-0002-1528-1808
Sharlene GovenderDepartment of Biochemistry and Microbiology, Nelson Mandela University, P.O. Box 77000, Gqeberha 6031, South Africa.ORCID 0000-0001-7117-2502
Maryna van de VenterDepartment of Biochemistry and Microbiology, Nelson Mandela University, P.O. Box 77000, Gqeberha 6031, South Africa.ORCID 0000-0003-3816-1419

Funding

CSIR through their African Laser Centre Program NAHA Taylor Will Trust NANational Research Foundation (NRF) innovation scholarship grant SFH180525334799/ MND200617532846NRF Development Grant NA
6 · The paper itself

Abstract

BACKGROUND/

objectivesTuberculosis remains a major public health crisis, and it is imperative to search for new antimycobacterial drugs. Natural products, including medicinal macrofungi, have been used as sources for the discovery of pharmaceuticals; however, research on their antimycobacterial activity remains limited. This study aimed to isolate and identify the bioactive compound responsible for antimycobacterial activity, thereby expanding on the limited knowledge regarding the antimicrobial activity and bioactive compounds present in

methodsBioassay-guided fractionation using column chromatography and preparative thin-layer chromatography were employed to isolate the active compound. Antimycobacterial activity against

resultsBioassay-guided fractionation led to the isolation of gymnopilene, which showed inhibitory activity against

conclusionsThis study highlights that macrofungi, such as

Indexed as

antimycobacterial activitycytotoxicitygymnopileneGymnopilus junoniusMycobacterium tuberculosis

Identifiers

PMID40001422
PMCPMC11851804

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.