ArticleBrain and behavior2025
Differential Abnormality in Regional Brain Spontaneous Activity and Functional Connectivity in Patients of Non-Acute Subcortical Stroke With Versus Without Global Cognitive Functional Impairment.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Dual Transcranial Direct Current Stimulation Modulates Hierarchical Functional Network Organization in Post-Stroke Cognitive Impairment: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2026Trial
- Functional connectivity alterations in patients with poststroke cognitive impairment: A resting-state functional magnetic resonance imaging study.World journal of radiology · 2026Article
- Hidden Rhythms of a Developing Brain: Multimetric rs-fMRI Insights Into Typical Youth Maturation.Human brain mapping · 2025Article
- Resting-State fMRI Reveals the Neural Correlates of Acupuncture in the Treatment of Vascular Cognitive Impairment.Clinical interventions in aging · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
introductionCognitive impairment after a stroke significantly affects patients' quality of life, yet not all strokes lead to such impairment, and the underlying reasons remain unclear. This study employs resting-state functional magnetic resonance imaging (rs-fMRI) to compare subcortical stroke patients with and without cognitive impairment. Our goal is to identify distinct abnormalities in regional brain spontaneous activity and functional connectivity (FC) to better understand the neural basis of post-stroke cognitive outcomes.
methodsA total of 62 first-ever non-acute subcortical stroke patients were classified into post-stroke with abnormal cognition (PSAC) and with normal cognition (PSNC) groups. Rs-MRI was utilized to assess regional homogeneity (ReHo) in 32 PSAC, 30 PSNC, and 62 age- and sex-matched healthy controls (HC). Then we performed the seed-based whole-brain FC analysis based on the ReHo results. A partial correlation analysis examined the relationship between altered ReHo or FC and Montreal Cognitive Assessment (MoCA) scores.
resultsIt showed varied activity in cognitive-related brain regions in both stroke groups compared to HC, such as the right superior frontal gyrus, the right middle temporal gyrus, the right postcentral gyrus, and the left cerebellar lobules. The PSAC group had increased activity in the bilateral inferior temporal gyrus as well. Significant differences in activity were also found between PSAC and PSNC groups, with the PSAC group showing decreased activity in the left gyrus rectus (REC) and increased activity in cerebellar lobules. FC analysis revealed decreased connections in the PSAC group, particularly involving the left REC. Activity and FC in left REC and cerebellum also significantly correlated with MoCA scores.
conclusionsThese findings suggest unique patterns of brain activity and connectivity in non-acute subcortical stroke patients with cognitive impairment, shedding light on potential neural mechanisms underlying post-stroke cognitive impairment. While the left REC may be a potential neural regulatory stimulus target in clinical applications.
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