ArticleMolecular and cellular biology1985
Suppression of tropomyosin synthesis, a common biochemical feature of oncogenesis by structurally diverse retroviral oncogenes.
Article in Molecular and cellular biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 137 citations in OpenAlex.
- Effects of increased CO2 on fish gill and plasma proteome.PloS one · 2014Article
- Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization.The EMBO journal · 2012Article
- Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells.Oncogene · 2004Article
- Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors.Oncogene · 2003Article
- Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma.British journal of cancer · 2003Article
- Cytoskeletal organization in tropomyosin-mediated reversion of ras-transformation: Evidence for Rho kinase pathway.Oncogene · 2001Article
- TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.The American journal of pathology · 2000Article
- Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Article
- Transformation-related expression of a low-molecular-mass tropomyosin isoform TM5/TM30nm in transformed rat fibroblastic cell lines.Journal of cancer research and clinical oncology · 1997Article
- Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Changes of tropomyosin isoforms during development of cross-fertilized sea urchin embryos.Development, growth & differentiation · 1996Article
- In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Regulation of microfilament organization and anchorage-independent growth by tropomyosin 1.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Forced expression of chimeric human fibroblast tropomyosin mutants affects cytokinesis.The Journal of cell biology · 1995Article
- Chromosome mapping of nine tropomyosin-related sequences in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.The Journal of cell biology · 1995Article
- Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin.The Journal of cell biology · 1994Article
- Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Differential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression.The Journal of cell biology · 1993Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify proteins whose production may be altered as a common event in the expression of structurally diverse oncogenes, we compared two-dimensional electropherograms of newly synthesized proteins from NIH/3T3 cell lines transformed by a variety of retroviral oncogenes, from cellular revertant lines, and from a line (433.3) which expresses the v-ras oncogene in response to corticosteroids. Most alterations in the synthesis of specific proteins detected by this approach appeared to be the result of selection during prolonged cultivation and were probably unrelated to the transformation process. However, we detected seven proteins whose synthesis was strongly suppressed in cell lines transformed by each of the six retroviral oncogenes we studied and whose production was fully or partially restored in two cellular revertant lines. Suppression of two of these proteins was also correlated with the initial appearance of morphological alteration during corticosteroid-induced oncogene expression in 433.3 cells. These proteins (p37/4.78 and p41/4.75) were identified as tropomyosins, a group of at least five cytoskeletal proteins. Transformation by the papovaviruses simian virus 40 and polyomavirus caused no suppression of synthesis of these tropomyosins. This indicates that suppression of tropomyosin synthesis is not a nonspecific response by cells to being forced to grow with the transformed phenotype but is specifically associated with oncogenesis by diverse retroviral oncogenes. The results are consistent with the hypothesis that the different biochemical processes initiated by expression of structurally diverse retroviral oncogenes may converge on a limited number of common targets, one of which is the mechanism which regulates the synthesis of tropomyosins.
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