Evidence map›Paper›PMID 40001192›Full record

ArticleBMC research notes2025

Identification of a novel transcript of mouse Sdha.

María J Esteban-Amo, Amaia Telleria, Dino Gobelli, Pablo Serrano-Lorenzo, Juan J Tellería, María T Pérez-García, Piotr Kozlowski, Miguel Á de la Fuente, María Simarro

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Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María J Esteban-Amo *Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47005, Valladolid, Spain.
Amaia Telleria *Department of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47005, Valladolid, Spain.
Dino GobelliDepartment of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47005, Valladolid, Spain.
Pablo Serrano-LorenzoHospital 12 de Octubre Research Institute (imas12), 28041, Madrid, Spain.
Juan J TelleríaDepartment of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47005, Valladolid, Spain.
María T Pérez-GarcíaUnit of Excellence Institute of Biomedicine and Molecular Genetics (IBGM), University of Valladolid and Spanish National Research Council (CSIC), 47003, Valladolid, Spain.
Piotr KozlowskiDepartment of Molecular Genetics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704, Poznan, Poland.
Miguel Á de la FuenteDepartment of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47005, Valladolid, Spain.
María SimarroDepartment of Cell Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47005, Valladolid, Spain. msimarrogrande@gmail.com.

Funding

Agencia Estatal de Investigación PID2023-150506OB-I00Consejería de Educación, Junta de Castilla y León VA172P20Consejería de Sanidad, Junta de Castilla y León GRS 2201/A/2020Programa Estratégico Instituto de Biomedicina y Genética Molecular (IBGM), Junta de Castilla y León CCVC8485
6 · The paper itself

Abstract

objectiveThis study aimed to identify novel isoforms of mouse succinate dehydrogenase complex flavoprotein subunit A (Sdha) arising from internal exon skipping, analogous to the process observed in human ortholog SDHA.

resultsWe identified a novel isoform, designated Δ3-10, which lacked the final 104 nucleotides of exon 3 and all of exons 4 through 10, yet did not alter the reading frame. The Δ3-10 Sdha cDNA was cloned into expression vectors, and overexpression resulted in a protein localized to the mitochondria. However, the endogenous Δ3-10 Sdha protein was not detected with the available antibodies.

Indexed as

Alternative SplicingSuccinate DehydrogenaseAnimalsCloning, MolecularExonsHumansMiceMitochondriaProtein IsoformsProtein IsoformsSuccinate DehydrogenaseIsoformsMitochondriaMouseSdha

Identifiers

PMID40001192
PMCPMC11863808

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