Evidence map›Paper›PMID 40001153›Full record

ArticleJournal of biological engineering2025

Carbon fluxes rewiring in engineered E. coli via reverse tricarboxylic acid cycle pathway under chemolithotrophic condition.

Jian-Hau Peng, Shou-Chen Lo, Yu-Ning Yu, Ya-Tang Yang, Yu-Chieh Chen, An-I Tsai, Dong-Yan Wu, Chu-Han Huang, Tien-Tsai Su, Chieh-Chen Huang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The Chemistry of COChemical reviews · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jian-Hau PengDoctoral Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, Taichung City and Taipei City, 402 and 115, Taiwan.
Shou-Chen LoDepartment of Life Sciences, National Chung Hsing University, Taichung City, 402, Taiwan.
Yu-Ning YuDepartment of Life Sciences, National Chung Hsing University, Taichung City, 402, Taiwan.
Ya-Tang YangDepartment of Electrical Engineering, National Tsing Hua University, Hsinchu City, 30013, Taiwan.
Yu-Chieh ChenDepartment of Life Sciences, National Chung Hsing University, Taichung City, 402, Taiwan.
An-I TsaiDepartment of Life Sciences, National Chung Hsing University, Taichung City, 402, Taiwan.
Dong-Yan WuDepartment of Life Sciences, National Chung Hsing University, Taichung City, 402, Taiwan.
Chu-Han HuangDepartment of Life Sciences, National Chung Hsing University, Taichung City, 402, Taiwan.
Tien-Tsai SuDepartment of Life Sciences, National Chung Hsing University, Taichung City, 402, Taiwan.
Chieh-Chen HuangDoctoral Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, Taichung City and Taipei City, 402 and 115, Taiwan. cchuang@dragon.nchu.edu.tw.
En-Pei Isabel ChiangDoctoral Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, Taichung City and Taipei City, 402 and 115, Taiwan. chiangisabel@nchu.edu.tw.

Funding

Ministry of Education Innovation and Development Center of Sustainable Agriculture (IDCSA) and the Advanced Plant and Food Crop Biotechnology Center (APFCBC) from The Featured Areas Research Center Program within the framework of the Higher Education Sprout ProjectNational Science and Technology Council 110-2320-B-005-008-MY3National Science and Technology Council 110-2321-B-005-008
6 · The paper itself

Abstract

backgroundA transgenic strain of Escherichia coli has been engineered to directly assimilate gaseous CO

resultsThis study found that KOR alone can support cellular maintenance under chemolithotrophic conditions, while additional expression of ACL enhances CO

conclusionsThis study demonstrates a novel strategy to engineer E. coli for CO

Indexed as

Carbon flux rewiringCO2 incorporationEscherichia coliProtein and nucleotide biosynthesisReverse tricarboxylic acid cycle

Identifiers

PMID40001153
PMCPMC11863533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.