Evidence map›Paper›PMID 40001141›Full record

ArticleJournal of nanobiotechnology2025

Influences of lead-based perovskite nanoparticles exposure on early development of human retina.

Cao Yang, Zhulin Du, Linqiang Mei, Xia Chen, You Liao, Lingling Ge, Jiahui Kang, Zhanjun Gu, Xiaotang Fan, Haiwei Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cao Yang *Southwest Eye Hospital, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zhulin Du *Key Laboratory of Extreme Environmental Medicine Ministry of Education, Department of Military Cognitive Psychology, School of Psychology, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Linqiang MeiInstitute of High Energy Physics and National Center for Nanoscience and Technology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, Chinese Academy of Sciences, Beijing, 100049, China.
Xia ChenSouthwest Eye Hospital, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
You LiaoInstitute of High Energy Physics and National Center for Nanoscience and Technology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, Chinese Academy of Sciences, Beijing, 100049, China.
Lingling GeSouthwest Eye Hospital, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Jiahui KangSouthwest Eye Hospital, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zhanjun GuInstitute of High Energy Physics and National Center for Nanoscience and Technology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, Chinese Academy of Sciences, Beijing, 100049, China. zjgu@ihep.ac.cn.
Xiaotang FanKey Laboratory of Extreme Environmental Medicine Ministry of Education, Department of Military Cognitive Psychology, School of Psychology, Third Military Medical University (Army Medical University), Chongqing, 400038, China. fanxiaotang@tmmu.edu.cn.
Haiwei XuSouthwest Eye Hospital, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. xuhaiwei@tmmu.edu.cn.

Funding

National Key Research and Development Program of China 2021YFA1101203
6 · The paper itself

Abstract

backgroundLead-based perovskite nanoparticles (Pb-PNPs) are widely utilized in the photovoltaic industry. However, due to their poor stability and high water solubility, lead often gets released into the environment, which can negatively impact the development of the central nervous system (CNS). As an extension of the CNS, the effects and mechanisms of Pb-PNPs on human retinal development have remained elusive.

objectivesWe aimed to investigate the effects of Pb-PNPs on human retinal development.

methodsHuman embryonic stem cell-derived three-dimensional floating retinal organoids (hEROs) were established to simulate early retinal development. Using immunofluorescence staining, biological-transmission electron microscopy analysis, inductively coupled plasma-mass spectrometry, two-dimensional element distribution detection, and RNA sequencing, we evaluated and compared the toxicity of CsPbBr

resultsOur findings revealed that CsPbBr

conclusionOverall, our study provides evidence of Pb-PNPs-induced developmental toxicity in the human retina, explores the potential mechanisms of CsPbBr

Indexed as

Calcium CompoundsLeadNanoparticlesOxidesRetinaTitaniumApoptosisCell DifferentiationCell ProliferationHuman Embryonic Stem CellsHumansOrganoidsSilicon DioxideCalcium CompoundsLeadOxidesperovskiteSilicon DioxideTitaniumDevelopingLead-based perovskite nanoparticlesOrganoidsPrenatal lead exposureRetinaToxicity

Identifiers

PMID40001141
PMCPMC11863764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.