Evidence map›Paper›PMID 40001136›Full record

ArticleTrials2025

Postoperative pain and quality of life assessment after endodontic preparation with rotary and reciprocating endodontic instruments: randomized clinical trial.

Wallace Vieira Mendes, Suellen Nogueira Linares Lima, Jacqueline Vitória do Nascimento Azevedo, Hadda Lyzandra Austríaco Leite, Patrícia Santos Oliveira, Meire Coelho Ferreira, Ceci Nunes Carvalho

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07714733 (The Effect of Using A Single Nickel-Titanium File System With Rotary And Reciprocation Kinematics in Different Apical Motion Modes on Postoperative Pain After Root Canal Treatment), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07714733 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Effect of Using A Single Nickel-Titanium File System With Rotary And Reciprocation Kinematics in Different Apical Motion Modes on Postoperative Pain After Root Canal Treatment

TypeinterventionalSponsorAlanya Alaaddin Keykubat UniversityRan2026 to 2027Enrolled120ConditionsApical Periodontitis, Postoperative Pain After Endodontic TreatmentArmsRoot Canal Treatment, Rotary Instrumentation, Reciprocating Instrumentation, Auto Apical Stop Mode, Auto Apical Reverse Mode
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wallace Vieira MendesUniCEUMA: Universidade Ceuma, São Luís, 125287, Brazil.ORCID https://orcid.org/0000-0002-3938-3921
Suellen Nogueira Linares LimaUniCEUMA: Universidade Ceuma, São Luís, 125287, Brazil.
Jacqueline Vitória do Nascimento AzevedoPostgraduate Program of Dentistry, CEUMA University, São Luís, Brazil.
Hadda Lyzandra Austríaco LeiteUFMA: Universidade Federal Do Maranhao, Maranhão, Brazil.
Patrícia Santos OliveiraUniCEUMA: Universidade Ceuma, São Luís, 125287, Brazil.
Meire Coelho FerreiraPostgraduate Program of Dentistry, CEUMA University, São Luís, Brazil.
Ceci Nunes CarvalhoPostgraduate Program of Dentistry, CEUMA University, São Luís, Brazil. ceci.carvalho@ceuma.br.ORCID https://orcid.org/0000-0002-1706-4081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative pain is a common complication following endodontic treatment, often caused by acute inflammatory responses in the periapical tissues. Several factors contribute to this, including inadequate instrumentation, apical extrusion of debris during canal preparation, and other aspects of the procedure. Advances in technology have led to the development of nickel-titanium (NiTi) instruments that have shown potential to reduce postoperative discomfort. The purpose of this study was to evaluate postoperative pain in patients undergoing endodontic treatment with different NiTi systems.

methodsThis randomized clinical trial will include 128 patients between the ages of 18 and 50 years with a diagnosis of pulp changes in molars without pain or radiographic lesions requiring endodontic treatment. Patients will be randomized to receive root canal preparation with the rotary ProTaper Ultimate rotary system or the Reciproc Blue reciprocating single-file system. The primary outcome will be the intensity of postoperative pain measured by a numerical rating scale (NRS-10 cm) in 24 h postoperatively. Secondary outcomes will include the intensity of postoperative pain measured by a visual analog scale (VAS-0-10 cm) at 6 and 12 h and spontaneous pain, occlusion sensitivity, and quality of life, assessed by the OHIP-14 questionnaire. DISCUSSION: Our null hypothesis is that there will be no significant difference in postoperative pain between the two systems. The results of this study will provide information on the incidence and intensity of postoperative pain after instrumentation of root canal instrumentation with different NiTi systems and may help improve patient outcomes and quality of life.

trial registrationBrazilian Clinical Trials Registry (REBEC): RBR-10kbw6nx. Registered on April 6, 2024.

Indexed as

Postoperative PainQuality of LifeRoot Canal PreparationRoot Canal TherapyAdolescentAdultEquipment DesignFemaleHumansMaleMiddle AgedNickelPain MeasurementRandomized Controlled Trials as TopicTime FactorsTitaniumNickelTitaniumtitanium nickelideEndodonticsRoot canal therapyToothache

Identifiers

PMID40001136
PMCPMC11863933

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.