ArticleJournal of nanobiotechnology2025
Nanowire-based squalene oleogel repairs skin photoaging.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Kaempferol-modified mesenchymal stem cell extracellular vesicle-mimetics promote photoaging repair by suppressing ADAM10.Cell communication and signaling : CCS · 2026Article
- FGF2 Enhances MSCs Secretome Therapy for Skin Photoaging by Delaying Senescence via iNAMPT/AMPK Signaling and Facilitating eNAMPT-Mediated Regenerative Crosstalk.Stem cell reviews and reports · 2026Article
- Lifestyle factors affecting the pathogenesis of androgenetic alopecia: a literature review.Frontiers in public health · 2026Review
- Gold@Mesoporous Polydopamine Nanocomposite Hydrogel Loaded with Estrogen for the Treatment of Skin Photoaging.International journal of nanomedicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Long-term exposure to ultraviolet B (UVB) radiation induces the accumulation of free radicals in the skin, resulting in oxidative damage and accelerated aging. As a natural anti-oxidant, squalene has been applied as a cosmetic additive. Nonetheless, the liquid oil state of squalene and its low solubility in water usually limits the practical application of squalene. Recently, phosphotungstate calcium nanowires has been synthesized to gelatinize oily solvents, making it feasible to fabricate stable oleogel formulation containing squalene. Herein, the squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel has been specifically designed and applied to treat skin photoaging. Such oleogel was comprised of oil-based structures that closely mimic the skin's natural lipids, resulting in enhanced skin penetration, better retention of active ingredients within the skin, and superior stability as compared to traditional hydrogel, especially under UVB exposure. It was found that the application of Sql/PWC oleogel on UVB-irradiated skin successfully decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen and skin barrier marker. Meanwhile, RNA-Sequencing results further revealed that the Sql/PWC oleogel alleviated UVB photo-damage through its antioxidant and anti-inflammatory activities in the skin, which were key factors in the aging process. We believe this study will not only bring new perspectives for skin photoaging treatment but also promotes the broader application of oleogel in the cosmetics industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.