Evidence map›Paper›PMID 40001098›Full record

ArticleBMC musculoskeletal disorders2025

Childhood abuse and health outcomes in patients with fibromyalgia: a cross-sectional exploratory study of the moderating effects of pain catastrophizing and mindfulness.

Jolin B Yamin, Samantha M Meints, Bethany D Pester, Madelyn Crago, Lauren Papianou, Asimina Lazaridou, Myrella Paschali, Vitaly Napadow, Robert R Edwards

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Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jolin B YaminDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 850 Boylston Street, Chestnut Hill, Boston, MA, 02467, USA. jyamin@bwh.harvard.edu.
Samantha M MeintsDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 850 Boylston Street, Chestnut Hill, Boston, MA, 02467, USA.
Bethany D PesterDepartment of Anesthesiology and Pain Medicine, University of Washington Medicine, Seattle, WA, USA.
Madelyn CragoUniversity of Massachusetts Medical School, Worcester, MA, USA.
Lauren PapianouDepartment of Psychology, St. Louis University, St. Louis, MO, USA.
Asimina LazaridouDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 850 Boylston Street, Chestnut Hill, Boston, MA, 02467, USA.
Myrella PaschaliDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 850 Boylston Street, Chestnut Hill, Boston, MA, 02467, USA.
Vitaly NapadowHarvard Medical School, Boston, MA, USA.
Robert R EdwardsDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 850 Boylston Street, Chestnut Hill, Boston, MA, 02467, USA.

Funding

Brain Mechanisms Underlying CBT-Related Reductions in FibromyalgiaR01AR064367 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R, NAPADOW, VITALY · 2014 to 2018
$4.0M
Neuroimaging Approaches to Deconstructing Acupuncuture for Chronic PainR01AT007550 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARRIS, RICHARD E, NAPADOW, VITALY · 2013 to 2019
$3.4M
PREventing Pain after Surgery: A feasibility and acceptability study of Acceptance and Commitment Therapy for the prevention of chronic post surgical pain (PREPS)K23AR077088 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI MEINTS, SAMANTHA M · 2021 to 2025
$1.0M
NCCIH NIH HHS R01 AT007550NIAMS NIH HHS K23 AR077088NIAMS NIH HHS R01 AR064367NIH HHS K23-AR077088NIH HHS R01-AR064367NIH HHS R01-AT007550
6 · The paper itself

Abstract

backgroundChildhood abuse has been linked to poorer health outcomes in individuals with fibromyalgia (FM), and this relationship may be affected by cognitive processes such as pain catastrophizing and mindfulness.

objectiveThis study investigated the impact of childhood abuse on pain-related symptoms and functioning in individuals with (FM) and examined how the critical psychosocial constructs of pain catastrophizing and mindfulness might moderate this relationship. We hypothesized that childhood abuse would be linked to greater physical symptoms and lower functioning, with pain catastrophizing and mindfulness influencing these associations.

methodsThe study sample consisted of 113 women with FM. Correlational analyses were conducted to examine the relationship between childhood abuse and health outcomes (pain severity, pain interference, fibromyalgia impact, and physical functioning). Moderation analyses were conducted to examine the impact of pain catastrophizing and mindfulness on the relationship between childhood abuse and health outcomes.

resultsAs expected, catastrophizing was generally associated with elevated pain-related symptomatology and reduced functioning, and higher levels of mindfulness were associated with reduced pain impact. However, contrary to our hypothesis, childhood abuse was not directly associated with pain severity, pain interference, fibromyalgia impact, or physical functioning. Pain catastrophizing and mindfulness were significant moderators of the relationship between childhood abuse and health outcomes. Specifically, childhood abuse was related to higher pain interference only at low levels of catastrophizing and was associated with greater fibromyalgia impact and reduced physical functioning only at high levels of mindfulness.

conclusionOur findings suggest that while childhood abuse did not directly impact pain-related outcomes in this sample of fibromyalgia patients, cognitive factors like pain catastrophizing and mindfulness play significant roles in moderating these effects. These results underscore the importance of assessing for cognitive and psychological factors in the management of fibromyalgia, especially for patients with a history of childhood abuse. Further research is needed to explore these relationships in more diverse samples and to develop personalized and targeted interventions for this patient population.

Indexed as

Adult Survivors of Child AbuseCatastrophizationFibromyalgiaMindfulnessAdultChildCross-Sectional StudiesFemaleHumansMiddle AgedPain MeasurementCatastrophizingChild abuseFibromyalgiaPsychosocial factors

Identifiers

PMID40001098
PMCPMC11854151

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.