Evidence map›Paper›PMID 40001018›Full record

Trial reportBMC psychiatry2025

Therapeutic effects of short-term trauma stabilization techniques combined with escitalopram in treating adolescent major depressive disorder: a pilot randomised controlled trial.

Jiating Xu, Jiajia Wu, Xiaojing Wang, Qianqian Chen, Ruizhi Xu, Yaoyan Xu, Xiuchao Geng, Yiping Tang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiating Xu *Psychosomatic Department, Taizhou Second People's Hospital, School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Jiajia Wu *Psychosomatic Department, Taizhou Second People's Hospital, School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Xiaojing WangPsychosomatic Department, Taizhou Second People's Hospital, School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Qianqian ChenPsychosomatic Department, Taizhou Second People's Hospital, School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Ruizhi XuPsychosomatic Department, Taizhou Second People's Hospital, School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Yaoyan XuPsychosomatic Department, Taizhou Second People's Hospital, School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China.
Xiuchao GengPsychosomatic Department, Taizhou Second People's Hospital, School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China. xiuchaogeng@163.com.
Yiping TangPsychosomatic Department, Taizhou Second People's Hospital, School of Medicine, Taizhou University, Taizhou, Zhejiang, 318000, China. zjtttyp@163.com.

Funding

Project of Taizhou Science and Technology Department 21ywb64The special project of "Provincial and Municipal Cooperation" of Zhejiang Philosophy and Social Science Planning Project in 2024 24SSHZ203YBZhejiang Medical and Health Science and Technology Plan Project 2022KY438Zhejiang Provincial Basic Public Welfare Research Plan LTGY24C060003
6 · The paper itself

Abstract

objectiveTo explore the efficacy of short-term trauma stabilization techniques combined with escitalopram in the treatment of adolescent major depressive disorder (MDD).

methodsA total of 80 patients with MDD who were hospitalized in the Psychosomatic Department of our hospital were selected and randomly divided into two groups: the escitalopram combined with short-term trauma stabilization technique group (study group) and the escitalopram combined with mental health education group (control group). Upon hospitalization, patients completed the adolescent self-rating life events check list (ASLEC), impact of event scale-revised (IES-R), 17-item Hamilton depression scale (HAMD-17) and Hamilton anxiety scale (HAMA). After 2 and 4 weeks of treatment, the IES-R, HAMD-17-17 and HAMA scores were reevaluated.

resultsThere were no significant differences in the ASLEC, IES-R, HAMD-17 or HAMA scores between the two groups at admission. Compared with that of the control group, the IES-R score of the study group was significantly improved at the 2nd week of treatment (P < 0.01). By the 4th week of treatment, the IES-R scores in the study group had further improved compared to the control group (P < 0.01). Additionally, the HAMD-17 and HAMA scores in the study group were significantly improved compared to the control group (P < 0.01).

conclusionEscitalopram combined with short-term trauma stabilization is more effective in the treatment of MDD than escitalopram with mental health education, warranting further exploration.

Indexed as

CitalopramEscitalopramMajor Depressive DisorderPsychotherapy, BriefSelective Serotonin Reuptake InhibitorsAdolescentCombined Modality TherapyFemaleHumansMalePilot ProjectsPsychiatric Status Rating ScalesTreatment OutcomeCitalopramEscitalopramSelective Serotonin Reuptake InhibitorsAdolescentEscitalopramMajor depressive disorderTrauma stabilization techniques

Identifiers

PMID40001018
PMCPMC11863421

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.