Evidence map›Paper›PMID 40001015›Full record

SynthesisBMC pediatrics2025

Incidence and predictors of mortality among neonates admitted with birth asphyxia to neonatal intensive care units in Ethiopia: a systematic review and meta-analysis.

Muluken Amare Wudu, Endalik Birrie Wondifraw, Fekadeselassie Belege Getaneh, Molla Kassa Hailu, Melaku Ashagrie Belete, Selamyhun Tadesse Yosef, Yemane Eshetu Bekalu, Tarikua Afework Birhanu

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muluken Amare WuduDepartment of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Wollo University, P. O. Box 1145, Dessie, 1145, Ethiopia. 385mule@gmail.com.
Endalik Birrie WondifrawDepartment of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Wollo University, P. O. Box 1145, Dessie, 1145, Ethiopia.
Fekadeselassie Belege GetanehDepartment of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Wollo University, P. O. Box 1145, Dessie, 1145, Ethiopia.
Molla Kassa HailuDepartment of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Wollo University, P. O. Box 1145, Dessie, 1145, Ethiopia.
Melaku Ashagrie BeleteDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, Dessie, 1145, Ethiopia.
Selamyhun Tadesse YosefDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Woldiya University, Woldiya, Ethiopia.
Yemane Eshetu BekaluDepartment of Public Health, ALKAN Health Sciences and Business College, Dessie, Ethiopia.
Tarikua Afework BirhanuDepartment of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Wollo University, P. O. Box 1145, Dessie, 1145, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBirth asphyxia is the second leading cause of neonatal mortality worldwide, including in Ethiopia, and remains a significant public health concern. Despite the availability of national data on neonatal mortality in Ethiopia, there remains a gap in understanding the specific incidence and predictors of mortality among asphyxiated neonates. To address this information gap, this meta-analysis was conducted to assess the incidence and predictors of mortality among asphyxiated neonates in Ethiopia.

methodsThis systematic review and meta-analysis was conducted in accordance with the PRISMA guidelines. Relevant studies were identified through various databases, including PubMed, CINAHL, Scopus, EMBASE, and Google Scholar. Data analysis of pooled estimates for mortality incidence and its predictors was performed via STATA 17 software with the DerSimonian and Laird model. Heterogeneity was assessed via Cochrane's Q-test and the I² statistic. Additionally, publication bias was evaluated through funnel plots, Egger's test, and Doi plots.

resultsOut of 68 identified studies, only 10 met the eligibility criteria, including a total of 4,866 participants. The pooled incidence rate of birth asphyxia mortality was 4 per 100 person-days (95% CI: 3-5), which was 35,754 person-days of observation. Furthermore, predictors of birth asphyxia mortality included: pregnancy complications (HR 1.52, 95% CI: 1.41-1.64), labor complications (HR 1.29, 95% CI: 1.15-1.44), severe hypoxic-ischemic encephalopathy (HR 1.67, 95% CI: 1.51-1.85), neonatal seizures (HR 1.23, 95% CI: 1.11-1.38), and comorbidities in neonates (HR 1.31, 95% CI: 1.24-1.39).

conclusionIn the current study, the pooled incidence of birth asphyxia mortality was high, falling short of the Sustainable Development Goals target and highlighting the need for immediate intervention. Additionally, pregnancy and labor complications, severe hypoxic-ischemic encephalopathy, neonatal seizures, and neonatal comorbidities were identified as predictors of birth asphyxia mortality. These findings underscore the urgent need to enhance early detection and intervention for pregnancy- and labor-related complications, as well as severe neonatal complications related to asphyxia, in to reduce mortality.

Indexed as

Asphyxia NeonatorumIntensive Care Units, NeonatalEthiopiaFemaleHumansIncidenceInfant MortalityInfant, NewbornPregnancyRisk FactorsBirth asphyxiaEthiopia, systemic review, meta- analysisIncidenceMortalityNeonatesPredictors

Identifiers

PMID40001015
PMCPMC11863858

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.