Evidence map›Paper›PMID 40000981›Full record

ArticleBMC cancer2025

Autoimmune disease and risk of lymphoma: analysis from real-world data and Mendelian randomization study.

Linquan Zhan, Siyuan Chen, Yingyue Liu, Tiange Lu, Zhuoya Yu, Xin Wang, Xiangxiang Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linquan ZhanDepartment of Hematology, Shandong Provincial Hospital, Shandong University, No.324, Jingwu Road, Jinan, 250021, Shandong, People's Republic of China.
Siyuan ChenShanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Ruijin Hospital, National Research Center for Translational Medicine at Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yingyue LiuDepartment of Hematology, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
Tiange LuDepartment of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
Zhuoya YuDepartment of Hematology, Shandong Provincial Hospital, Shandong University, No.324, Jingwu Road, Jinan, 250021, Shandong, People's Republic of China.
Xin WangDepartment of Hematology, Shandong Provincial Hospital, Shandong University, No.324, Jingwu Road, Jinan, 250021, Shandong, People's Republic of China. xinw007@126.com.
Xiangxiang ZhouDepartment of Hematology, Shandong Provincial Hospital, Shandong University, No.324, Jingwu Road, Jinan, 250021, Shandong, People's Republic of China. xiangxiangzhou@sdu.edu.cn.

Funding

Academic Promotion Programme of Shandong First Medical University No. 2019QL018National Natural Science Foundation No.82270200, No.82070203Translational Research Grant of NCRCH No.2021WWB02, No.2020ZKMB01
6 · The paper itself

Abstract

backgroundAutoimmune diseases (AIDs) appear to be the primary predisposing factors for lymphoma. This study aims to investigate the causal effects between AIDs and lymphomagenesis.

methodsA two-sample Mendelian randomization (MR) framework was employed to estimate the causal effect through UK Biobank (UKB) and FinnGen cohorts. Patients with histories of AIDs and diagnosed with lymphoma were enrolled in real-world studies.

resultsMR analysis investigated the potential causal effect of AIDs on the risks of lymphoma [odd ratio (OR) = 1.001, 95% confidence interval (CI) = 1.000-1.002, p = 0.040]. In our real-world data, there are no significantly increased risks for lymphoma when analyzing ORs for the history of rheumatoid arthritis (RA) and psoriasis (PsO) (OR 1.027, 95% CI = 0.516-2.04 for RA, and OR 1.022, 95% CI = 0.442-2.365 for PsO). The serum albumin (ALB) and sialic acid (SA) levels were independent prognostic factors for both progression-free survival (PFS) and overall survival (OS) in AIDs-associated lymphoma (AAL) patients.

conclusionsOur results confirmed the causal relationships between AIDs and risks of lymphoma. Serum ALB and SA levels have demonstrated a vital influence on outcomes of AAL patients, in which the IL-17 pathway might play an active role.

Indexed as

Autoimmune DiseasesLymphomaAdultAgedFemaleGenetic Predisposition to DiseaseHumansMaleMendelian Randomization AnalysisMiddle AgedPrognosisRisk FactorsAutoimmune diseaseClinical characteristicsGenome-wide association studiesLymphomaMendelian randomizationPrognosis

Identifiers

PMID40000981
PMCPMC11863826

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.