Evidence map›Paper›PMID 40000883›Full record

ArticleScientific reports2025

Factors associated with reduction in quality of life after SARS-CoV-2 infection.

Christian Neumann, Tim J Hartung, Klara Boje, Thomas Bahmer, Julian Keil, Wolfgang Lieb, Katrin Franzpoetter, Julius Welzel, Irina Chaplinskaya-Sobol, Matthias Endres and 25 more

Erratum issuedAbstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Christian Neumann *Neurology Department, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany. Christian.Neumann@uksh.de.ORCID http://orcid.org/0000-0002-5891-1937
Tim J Hartung *Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Bonhoefferweg 3, 10117, Berlin, Germany.
Klara BojeDepartment of General Psychology I and Biological Psychology, Christian-Albrechts-Universität Zu Kiel, Neufeldstraße 4a, 24118, Kiel, Germany.
Thomas BahmerInternal Medicine Department I, Leibniz Lung Clinic, University Hospital Schleswig Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.
Julian KeilDepartment of General Psychology I and Biological Psychology, Christian-Albrechts-Universität Zu Kiel, Neufeldstraße 4a, 24118, Kiel, Germany.
Wolfgang LiebInstitute for Epidemiology, Christian-Albrechts-University Kiel, Niemannsweg 11, 24105, Kiel, Germany.
Katrin FranzpoetterInstitute for Epidemiology, Christian-Albrechts-University Kiel, Niemannsweg 11, 24105, Kiel, Germany.
Julius WelzelNeurology Department, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.
Irina Chaplinskaya-SobolDepartment of Medical Informatics, University Medical Center Goettingen, Von-Siebold-Str. 3, 37075, Goettingen, Germany.
Matthias EndresDepartment of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Bonhoefferweg 3, 10117, Berlin, Germany.
Johanna GeritzNeurology Department, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.
Karl Georg HaeuslerDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Peter HeuschmannInstitute of Clinical Epidemiology and Biometry, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.
Andreas HinzDepartment of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany.
Sina M PützDepartment I of Internal Medicine, Center for Integrated Oncology Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Str. 62, Cologne, Germany.
Anna SchäferInstitute of Clinical Epidemiology and Biometry, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.
Carolin NuernbergerInstitute of Clinical Epidemiology and Biometry, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.
Lena SchmidbauerInstitute of Clinical Epidemiology and Biometry, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.
Michael KrawczakInstitute of Medical Informatics and Statistics, Kiel University, University Medical Center Schleswig-Holstein Campus Kiel, Arnold-Heller-Str. 3, 50937, Cologne, Germany.
Anne-Kathrin RußInstitute for Epidemiology, Christian-Albrechts-University Kiel, Niemannsweg 11, 24105, Kiel, Germany.
Lilian KristInstitute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Schumannstr. 20, 10117, Berlin, Germany.
Thomas KeilDepartment Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital Wuerzburg, Am Schwarzenberg 15, 97080, Wuerzburg, Germany.
Jennifer KudelkaNeurology Department, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.
Corina MaetzlerNeurology Department, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.
Anja Mehnert-TheuerkaufDepartment of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany.
Felipe A MontellanoDepartment of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.
Caroline MorbachDepartment Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital Wuerzburg, Am Schwarzenberg 15, 97080, Wuerzburg, Germany.
Sein SchmidtClinical Study Center, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Anna-Louisa-Karsch-Straße 2, 10178, Berlin, Germany.
Jan HeyckendorfInternal Medicine Department I, Leibniz Lung Clinic, University Hospital Schleswig Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.
Flo SteigerwaldDepartment of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Bonhoefferweg 3, 10117, Berlin, Germany.
Stefan StoerkDepartment Clinical Research and Epidemiology, Comprehensive Heart Failure Center, University Hospital Wuerzburg, Am Schwarzenberg 15, 97080, Wuerzburg, Germany.
Christina LemhoeferInstitute of Physical and Rehabilitation Medicine, Jena University Hospital/Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany.
Stefan SchreiberInternal Medicine Department I, Leibniz Lung Clinic, University Hospital Schleswig Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.
Carsten Finke *Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Bonhoefferweg 3, 10117, Berlin, Germany.
Walter Maetzler *Neurology Department, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term changes in health-related quality of life (HrQoL) after SARS-CoV-2 infection are common, but their causes and consequences are poorly understood. This prospective, population-based study examined associations between HrQoL and 49 demographic and clinical variables. HrQoL was assessed using the European Quality-of-Life-5-Dimensions-5-Level-Version in 3,475 participants (56% female; aged 18-88 years) approximately 9 months (baseline) and 26 months (follow-up) after their initial infection. Results were compared with the demographic and clinical variables using recursive feature elimination and random forest regression analyses. A statistically significant improvement in HrQoL was observed during the observation period. At baseline, 39% of the variance in HrQoL was explained by fatigue, muscle pain, number of remaining symptoms (RS), perceived stress, and age. At follow-up, fatigue, RS, perceived stress, muscle and joint pain, and age explained 54% of the variance in HrQoL. Changes in HrQoL were associated with changes in fatigue, RS, and perceived stress, meaning that if these decreased from baseline to follow-up, then HrQoL was improved. However, it was not possible to predict whether an individual's HrQoL would improve or worsen 1 year later based on baseline variable scores. The aforementioned symptoms are specifically associated with impairment in the population's usual activities.

Indexed as

COVID-19Quality of LifeAdolescentAdultAgedAged, 80 and overFatigueFemaleHumansMaleMiddle AgedProspective StudiesSARS-CoV-2Young AdultAgeCOVID-19EQ-5D-5LFatiguePost-acute COVID-19 syndromeQuality of life

Identifiers

PMID40000883
PMCPMC11861590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.