ArticleScientific reports2025
The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Correlations Between Immuno-Inflammatory Biomarkers and Hematologic Indices Stratified by Immunologic SNP Genotypes.Journal of clinical medicine · 2025Article
- Long non-coding RNA EPB41L4A-AS1 as a biomarker of sepsis alleviates inflammatory response by targeting miR-146a-5p.European journal of medical research · 2025Article
- IFN-γ +874 T/A Is Associated with High Levels of Sera CPK in Patients with Inflammatory Myopathies.Current issues in molecular biology · 2025Article
- The Role of Inflammatory Factors in the Pathogenesis of Gestational Diabetes Mellitus and May Be Potential Biomarkers for Its Diagnosis and Prognosis.Human mutation · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biomarkers associated with sepsis have not yet been completely elucidated. The objective of the current article is to investigate whether inflammatory factors act as risk factors for sepsis. The study included 320 adult patients with sepsis, which were enrolled as experimental group. In addition, 560 healthy individuals from the same period were selected as the control group. Cytokine expressions were measured using flow cytometry with fluorescence, and gene polymorphisms were analyzed through the PCR-RFLP technique. Significantly higher expression levels of IL-1, IL-6, IL-10, and TNF-α, were detected (p < 0.05). This study also identified specific polymorphisms IL-1B -511 C/T, IL-10 -1082 G/A, IL-6 -174 G/C, and TNF-α -308 G/A, that were significantly associated with an increased risk of sepsis (p < 0.05). The expression levels of IL-1, IL-6, IL-10, and TNF-α are associated with an increased risk of sepsis. Additionally, the polymorphisms IL-1B -511 C/T, IL-6 -174 G/C, IL-10 -1082 G/A, IFN-γ + 874 A/T, and TNF-α -308 G/A are also linked to sepsis risk in the Chinese population.
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