Evidence map›Paper›PMID 40000673›Full record

ArticleScientific reports2025

Proposal of integrated clinical pathway in the management of perioperative recurrent laryngeal nerve injury post thyroid and parathyroid surgery.

Khairil Afif Mahmud, Mawaddah Azman, Rohaizak Muhammad, Marina Mat Baki

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Khairil Afif MahmudDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz UKM, Level 9, Department of Otorhinolaryngology, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia.
Mawaddah AzmanDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz UKM, Level 9, Department of Otorhinolaryngology, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia.
Rohaizak MuhammadDepartment of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz UKM, Kuala Lumpur, Malaysia.
Marina Mat BakiDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz UKM, Level 9, Department of Otorhinolaryngology, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Kuala Lumpur, Malaysia. marinamb@ukm.edu.my.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early intervention is the current paradigm shift in the management of recurrent laryngeal nerve (RLN) injury post thyroidectomy and parathyroidectomy. Thus, an integrated clinical pathway is needed to enable early detection of RLN injury. A prospective longitudinal study was conducted from 2015 until 2021 in a single tertiary centre. A clinical pathway was developed where routine perioperative laryngeal assessments were implemented for all patients who underwent thyroidectomy and parathyroidectomy. Following an RLN injury, early surgical intervention was performed for unilateral vocal fold paralysis (UVFP). Data on patient demographics, risk factors, timing of RLN injury detection and type of intervention received were recorded in a proforma and analysed. 397 patients were included, involving 660 nerves at risk. The incidences of permanent RLN injury following thyroidectomy and parathyroidectomy were 5% and 1.8% respectively. The usage of intraoperative neuromonitoring was the only significant factor that affected the RLN injury according to multivariate analysis. 15% of RLN injuries were detected intraoperatively and 98% within two days. 70% of patients with UVFP received intervention in less than two weeks. The integrated clinical pathway has improved the validity of RLN injury incidence. It allows early detection of RLN injury and facilitates immediate intervention.

Indexed as

Critical PathwaysParathyroidectomyPostoperative ComplicationsRecurrent Laryngeal Nerve InjuriesThyroidectomyAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesRisk FactorsVocal Cord ParalysisComplicationsParathyroidectomyRecurrent laryngeal nerve injuryRisk factorsThyroidectomyVocal fold paralysis

Identifiers

PMID40000673
PMCPMC11861973

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.