Evidence map›Paper›PMID 40000636›Full record

ArticleNature communications2025

A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration.

Friederike Grandke, Tobias Fehlmann, Fabian Kern, David M Gate, Tobias William Wolff, Olivia Leventhal, Divya Channappa, Pascal Hirsch, Edward N Wilson, Eckart Meese and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Challenge-based ex vivo immune profiling reveals stimulus-dependent peripheral immune reprogramming in Alzheimer's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  7. Are Different Populations Fairly Represented in Single-Cell Omic Atlases?bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Cell death-associated genes as novel diagnostic biomarkers for autism spectrum disorder.Apoptosis : an international journal on programmed cell death · 2026
    Article
  13. Review
  14. Review
  15. Long-read genome sequencing and multi-omics in aging and neurodegeneration.medRxiv : the preprint server for health sciences · 2025
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Friederike GrandkeClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID http://orcid.org/0000-0001-6185-1472
Tobias FehlmannClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.
Fabian KernClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID http://orcid.org/0000-0002-8223-3750
David M GateDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-0481-9657
Tobias William WolffClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID http://orcid.org/0009-0002-5717-2666
Olivia LeventhalDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Divya ChannappaDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Pascal HirschClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID http://orcid.org/0000-0003-4152-9931
Edward N WilsonDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-0640-5247
Eckart MeeseDepartment of Human Genetics, Saarland University, 66421, Homburg/Saar, Germany.
Chuanyu LiuMGI Group, San Jose, CA, USA.
Quan ShiMGI Group, San Jose, CA, USA.
Matthias FlothoClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.ORCID http://orcid.org/0009-0006-4374-0801
Yongping LiClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.
Cynthia ChenMGI Group, San Jose, CA, USA.
Yeya YuMGI Group, San Jose, CA, USA.
Jiangshan XuMGI Group, San Jose, CA, USA.
Michael JunkinMGI Group, San Jose, CA, USA.
Zhifeng WangMGI Group, San Jose, CA, USA.
Tao WuMGI Group, San Jose, CA, USA.
Longqi LiuMGI Group, San Jose, CA, USA.
Yong HouMGI Group, San Jose, CA, USA.
Katrin I AndreassonDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0001-8391-4155
Jenny S GansenClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany.
Elvira MassLife and Medical Sciences Institute, Developmental Biology of the Immune System, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-2318-2356
Kathleen PostonDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-3424-7143
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA. twc@stanford.edu.ORCID http://orcid.org/0000-0001-5893-0831
Andreas KellerClinical Bioinformatics, Saarland University, 66123, Saarbrücken, Germany. andreas.keller@ccb.uni-saarland.de.ORCID http://orcid.org/0000-0002-5361-0895

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 466168626Michael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation) 14446, 17047 (subc. 125491594)Michael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation) MJFF-021418
6 · The paper itself

Abstract

The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference and chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our understanding of observed peripheral changes in neurodegeneration. Here, we employ single-cell gene expression profiling of over 909k peripheral blood mononuclear cells (PBMCs) from 121 healthy individuals, 48 patients with mild cognitive impairment (MCI), 46 with Parkinson's disease (PD), 27 with Alzheimer's disease (AD), and 15 with both PD and MCI. The dataset is interactively accessible through a freely available website ( https://www.ccb.uni-saarland.de/adrcsc ). In this work, we identify disease-associated changes in blood cell type composition and the gene expression in a sex-specific manner, offering insights into peripheral and solid tissue signatures in AD and PD.

Indexed as

Alzheimer DiseaseCognitive DysfunctionLeukocytes, MononuclearNeurodegenerative DiseasesParkinson DiseaseSingle-Cell AnalysisAgedAged, 80 and overFemaleGene Expression ProfilingHumansMaleMiddle AgedSex CharacteristicsSex FactorsTranscriptome

Identifiers

PMID40000636
PMCPMC11862118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.