Evidence map›Paper›PMID 40000446›Full record

Observational studyBJOG : an international journal of obstetrics and gynaecology2025

Reactive Hypoglycaemia at Glucose Tolerance Test-Another Presentation of Gestational Diabetes: A Multicentre Retrospective Study.

Sana Rehman, Salsabeel Kazi, Haashim Shah, Nicola Wallis, Pradhiki Mahindra, Bassel H Al Wattar, Melissa Whitten, Katherine Lattey, Molly Parrington, Rose Turner and 2 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sana RehmanEGA Institute for Women's Health, University College London, London, UK.ORCID https://orcid.org/0009-0005-5236-6375
Salsabeel KaziEGA Institute for Women's Health, University College London, London, UK.
Haashim ShahCornell University, Ithaca, New York, USA.
Nicola WallisEGA Institute for Women's Health, University College London, London, UK.
Pradhiki MahindraEGA Institute for Women's Health, University College London, London, UK.
Bassel H Al WattarComprehensive Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.ORCID https://orcid.org/0000-0001-8287-9271
Melissa WhittenEGA Institute for Women's Health, University College London, London, UK.
Katherine LatteyUniversity of Bristol, Bristol, UK.
Molly ParringtonUniversity of Bristol, Bristol, UK.
Rose TurnerUniversity of Bristol, Bristol, UK.
Christy BurdenUniversity of Bristol, Bristol, UK.
Dimitrios SiassakosEGA Institute for Women's Health, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess obstetric outcomes in pregnant women with 'reactive hypoglycaemia' (RH) during an oral glucose tolerance test (OGTT), defined as a 2-h blood glucose level lower than the fasting value.

designRetrospective observational study.

settingTwo tertiary maternity units in the United Kingdom. POPULATION: A total of 1498 women with singleton pregnancies attending for an OGTT between April 2019 and July 2020.

methodsMaternal and neonatal outcomes were compared between three groups: gestational diabetes, reactive hypoglycaemia and normal OGTT. Both logistic and linear regression models were used, which adjusted for maternal age at booking, ethnicity, parity and BMI.

main outcome measuresAbdominal circumference > 95th centile, polyhydramnios, gestational age at delivery, preterm birth, birthweight, neonatal hypoglycaemia, admission to neonatal unit, perinatal mortality.

resultsOf the 1498 women, 26.7% (n = 400) had reactive hypoglycaemia, 27.8% (n = 417) GDM and 45.4% (n = 681) normal GTT. The reactive hypoglycaemia group were twice as likely to develop polyhydramnios compared with both the GDM (OR 2.77, 95% CI 1.40-5.50) and control groups (OR 2.47, 95% CI 1.31-4.65). Relative to those with GDM, women with reactive hypoglycaemia had a similar mean birthweight (mean difference 59.4 g, p = 0.06) but were less likely to experience neonatal hypoglycaemia (OR 0.30, 95% CI 0.001-0.15) or preterm birth (OR 0.33, 95% CI 0.18-0.60). No differences were found in maternal hypertensive disorders, abdominal circumference > 95th centile, shoulder dystocia, Apgar < 7, cord pH, admission to neonatal unit or perinatal mortality.

conclusionWomen with reactive hypoglycaemia in this sample were at risk of adverse outcomes frequently associated with diabetes, including polyhydramnios.

Indexed as

Diabetes, GestationalHypoglycemiaAdultBlood GlucoseFemaleGlucose Tolerance TestHumansInfant, NewbornPolyhydramniosPregnancyPregnancy OutcomePremature BirthRetrospective StudiesUnited KingdomBlood Glucoseobstetric outcomesoral glucose tolerance testreactive hypoglycaemia

Identifiers

PMID40000446
PMCPMC12051243

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.