Evidence map›Paper›PMID 40000338›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Impact of deep brain stimulation on cognitive impairment in Parkinson's disease: A retrospective longitudinal study.

You Ni, Yan Xiao, Bo Shen, Yi-Min Sun, Jue Zhao, Bin Wu, Yi-Lin Tang, Feng-Tao Liu, Jian Wang, Jian-Jun Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

You NiDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Yan XiaoDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Bo ShenDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Yi-Min SunDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Jue ZhaoDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Bin WuDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Yi-Lin TangDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Feng-Tao LiuDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Jian WangDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: wangjian_hs@fudan.edu.cn.
Jian-Jun WuDepartment of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: wujianjun@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for improving motor symptoms, non-motor symptoms, and quality of life (QOL) in patients with advanced Parkinson's disease (PD). However, its effects on patients with cognitive impairment (CI) remain controversial due to the unique challenges and risks posed by cognitive decline. This study aimed to evaluate the mid- to long-term impact of STN-DBS on motor function, non-motor symptoms, and QOL in PD patients with CI. A retrospective cohort of 72 PD patients who underwent STN-DBS and 73 non-DBS patients was analyzed. Baseline and follow-up assessments (minimum one-year follow-up) included motor function (MDS-UPDRS III "off"), non-motor symptoms (NMSS), QOL (PDQ-8), and cognitive function (MMSE). Patients were stratified into a CI cohort based on education-adjusted MMSE cutoffs, with 30 patients in the STN-DBS group and 23 in the non-DBS group. Over two years, the STN-DBS group showed significant improvements in motor function, reduced medication burden (LEDD), and enhanced QOL. Notably, patients with CI in the STN-DBS group achieved better long-term motor and non-motor outcomes compared to the non-DBS group. These results highlight the potential of STN-DBS to offer sustained benefits for cognitively impaired PD patients, though further research is necessary to confirm its long-term safety and efficacy.

Indexed as

Cognitive DysfunctionDeep Brain StimulationParkinson DiseaseAgedFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedQuality of LifeRetrospective StudiesSubthalamic NucleusTreatment OutcomeCognitive impairmentDeep brain stimulationParkinson's diseaseQuality of life

Identifiers

PMID40000338
PMCPMC12047459

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.