Evidence map›Paper›PMID 40000121›Full record

ArticleAJNR. American journal of neuroradiology2025

Patterns of Epidural Patch Distribution: The Influence of Spinal Level, Injection Technique, and Patch Volume/Composition on Craniocaudal and Ventral Epidural Dispersion.

Daniel Montes, Samantha L Pisani Petrucci, Debayan Bhaumik, Nadya Andonov, Peter Lennarson, Andrew L Callen

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel MontesFrom the Department of Radiology, Neuroradiology Section (D.M., S.L.P.P., D.B., N.A., A.L.C.), University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID https://orcid.org/0000-0002-5933-9397
Samantha L Pisani PetrucciFrom the Department of Radiology, Neuroradiology Section (D.M., S.L.P.P., D.B., N.A., A.L.C.), University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Debayan BhaumikFrom the Department of Radiology, Neuroradiology Section (D.M., S.L.P.P., D.B., N.A., A.L.C.), University of Colorado Anschutz Medical Campus, Aurora, Colorado.ORCID https://orcid.org/0000-0002-9324-9256
Nadya AndonovFrom the Department of Radiology, Neuroradiology Section (D.M., S.L.P.P., D.B., N.A., A.L.C.), University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Peter LennarsonDepartment of Neurosurgery (P.L.), University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Andrew L CallenFrom the Department of Radiology, Neuroradiology Section (D.M., S.L.P.P., D.B., N.A., A.L.C.), University of Colorado Anschutz Medical Campus, Aurora, Colorado andrew.callen@cuanschutz.edu.ORCID https://orcid.org/0000-0003-2315-7767

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeEpidural patching with autologous blood and/or fibrin sealant is a common treatment for spinal CSF leaks, yet the factors influencing patch distribution remain poorly understood. This study aimed to analyze the craniocaudal (CC) and ventral epidural (VE) extent of epidural patch material and investigate the impact of variables such as patch volume (PV), composition, spinal level of injection, and patient habitus on distribution patterns. MATERIALS AND

methodsThis retrospective, cross-sectional cohort study included patients who underwent CT-guided epidural patching from January to September 2024. Inclusion criteria were age ≥18 years, dorsal interlaminar (DI) or transforaminal (TFO) epidural patching by using blood, fibrin, or both, and immediate postpatch imaging capturing the entire patch extent. Patch distribution was assessed for CC and VE spread. Statistical analyses included linear and logistic regression models, with multivariate analyses adjusting for confounders.

resultsOf 152 patients patched during the study period, 33 met inclusion criteria (mean age 45.4 years; 84.1% women) with 44 spinal levels patched: cervical (6.8%), thoracic (68.2%), and lumbar (25%). Mean PV per needle was 7.2 mL, with a mean CC spread of 4.6 spinal levels. There was a positive relationship between PV and CC spread across all spinal levels (β = 0.29,

conclusionsThe distribution of epidural patch material is influenced by spinal level, PV, composition, and injection approach. Cervical patches provide the greatest spread efficiency relative to volume, while DI approaches enhance CC spread but reduce ventral dispersion.

Indexed as

Blood Patch, EpiduralCerebrospinal Fluid LeakFibrin Tissue AdhesiveAdultCross-Sectional StudiesEpidural SpaceFemaleHumansInjections, EpiduralMaleMiddle AgedRadiography, InterventionalRetrospective StudiesTomography, X-Ray ComputedFibrin Tissue Adhesive

Identifiers

PMID40000121
PMCPMC12453460

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.