Evidence map›Paper›PMID 40000086›Full record

ArticleBMJ open2025

Protocol for a randomised controlled trial of a weight maintenance intervention to promote fat loss in pregnant individuals with obesity.

Leanne M Redman, Suzanne Phelan, John W Apolzan, Robbie A Beyl, Abby D Altazan, Madison S Dickey, Emerson Simeon, Emily W Flanagan, Hannah E Cabre, Joshua R Sparks and 6 more

2 registry-linked trialsAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04731688 nacompletednot on this map

A Weight Maintenance Program Promoting Fat Loss in Pregnancy in Women With Obesity

TypeinterventionalSponsorPennington Biomedical Research CenterRan2021 to 2025Enrolled100ConditionsGestational Weight Gain, ObesityArmsWeight Maintenance Group
NCT07309536 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES): A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of New BrunswickRan2026 to 2027Enrolled40ConditionsGut Microbiome, Body Composition, Adherence, MetabolitesArmsMediterranean Diet Nutrition Program, Standard Diet Education Program
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Leanne M RedmanLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA leanne.redman@pbrc.edu.ORCID http://orcid.org/0000-0002-7267-7374
Suzanne PhelanDepartment of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, California, USA.
John W ApolzanLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID http://orcid.org/0000-0001-8492-7820
Robbie A BeylLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Abby D AltazanLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Madison S DickeyLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Emerson SimeonLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Emily W FlanaganLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Hannah E CabreLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Joshua R SparksLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Maryam KebbeLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Aaron B CaugheyDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.
Amy M ValentDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.
Daniel S HsiaLouisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Elaine YinDepartment of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, California, USA.
Sarah K KeadleDepartment of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, California, USA.

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
Training in Obesity ResearchT32DK064584 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN, Christopher D Morrison · 2003 to 2026
$5.3M
Promoting fat loss during pregnancy in women with grade 2 and 3 obesityR01DK124806 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI PHELAN, SUZANNE, REDMAN, LEANNE MAREE · 2020 to 2024
$3.2M
NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK124806NIDDK NIH HHS T32 DK064584NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

introductionIn pregnancy, people with obesity or excess adiposity are prone to excess gestational weight gain (GWG) and have the highest risks for multiple maternal morbidities. Epidemiological studies suggest that the lowest incidence of adverse maternal and infant outcomes occurs with GWG lower than current recommendations (<5 kg) and with gestational weight maintenance, resulting in fat mass loss, in those with obesity. Data from randomised clinical trials are needed to evaluate the efficacy of a fat mass loss intervention on pregnancy outcomes. The objective of this proof-of-principle randomised controlled trial is to test the effect of a gestational fat mass loss intervention in pregnant individuals with obesity on changes in weight, fat mass and cardiometabolic disease risk factors. METHODS AND ANALYSIS: In this two-site randomised parallel group, 100 women (30% black; 30% Hispanic) with pre-existing obesity (31.0≤body mass index≤55.0 kg/m ETHICS AND DISSEMINATION: The trial has been approved by the Pennington Biomedical Research Center Institutional Review Board, is monitored by an independent data and safety monitoring board and will be conducted in agreement with the Declaration of Helsinki. All results, positive, negative and inconclusive, will be disseminated at national and/or international scientific meetings and in peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER: NCT04731688.

Indexed as

Body Weight MaintenanceObesityPregnancy ComplicationsWeight LossAdultCardiometabolic Risk FactorsFemaleGestational Weight GainHumansPregnancyPregnancy OutcomeRandomized Controlled Trials as TopicNUTRITION & DIETETICSObesityPregnancyPregnant WomenRandomized Controlled Trial

Identifiers

PMID40000086
PMCPMC11865736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.