ArticleJournal of the American Chemical Society2025
Nickel-Catalyzed Branched Hydroalkylation of Alkenes with Diazo Compounds.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Transition-Metal Hydride Catalysis Meets Nitrenoid Transfer: Design Principles for Precision C-N Bond Formation.Accounts of chemical research · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A nickel-catalyzed, branched-selective hydroalkylation of alkenes using diazo compounds has been developed. This protocol enables the functionalization of both activated and unactivated alkenes, in both directed and nondirected manners. Mono-, di-, and trisubstituted alkenes can be effectively transformed. Highly diastereoselective hydroalkylations have also been demonstrated. The method provides a novel approach for introducing an α-carbonyl moiety to alkenes, which is currently inaccessible by existing methods. Preliminary mechanistic investigations suggest a carbene-type mechanism, which is unusual for nickel catalysis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.