Trial reportNeurology2025
Transcranial Magnetic Stimulation Combined With Multimodality Aphasia Therapy for Chronic Poststroke Aphasia: A Randomized Clinical Trial.
Trial report in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04102228 (A Randomized Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation (rTMS) and Multi-Modal Aphasia Treatment (M-MAT) for Post-Stroke Non-Fluent Aphasia
Who cites it
8 citing papers in PubMed.
- Effectiveness of non-pharmacological therapies for poststroke aphasia: a protocol of a systematic review and network meta-analysis.BMJ open · 2026Article
- Code ICH: Building Consensus in Pediatric Intracerebral Hemorrhage.Journal of the American Heart Association · 2026Article
- Transcranial Magnetic Stimulation Combined with Speech-Language Therapy for Post-Stroke Aphasia Recovery: A Systematic Review and Network Meta-Analysis.Therapeutics and clinical risk management · 2026Review
- Fixel-Based White Matter Correlates of Sentence Comprehension in Post-Stroke Aphasia.Brain sciences · 2025Article
- Language Functional Connectivity Alterations During Resting State in Brain Arteriovenous Malformation Patients.CNS neuroscience & therapeutics · 2025Article
- Telerehabilitation Delivery of Multi-Modality Aphasia Therapy (M-MAT Tele): A Pilot Feasibility Trial.International journal of telerehabilitation · 2025Article
- Clinical outcomes of rTMS-augmented rehabilitation for post-stroke language and swallowing dysfunction: a sham-controlled prospective study with theory-informed interpretation.Frontiers in neurologyArticle
- Effects of non-invasive brain stimulation on spontaneous neural activity in post-stroke aphasia: a protocol for a coordinate-based meta-analysis of fALFF studies.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIntensive speech therapy may improve recovery from poststroke aphasia. Further evidence suggests that pairing repetitive transcranial magnetic stimulation (rTMS) with intensive speech therapy might augment outcomes. This sham-controlled randomized clinical trial evaluated the efficacy of 1-Hz rTMS over the right pars triangularis combined with multimodality aphasia therapy (M-MAT) in chronic poststroke aphasia.
methodsA parallel-group, double-blind, sham-controlled randomized clinical trial was conducted between April 2021 and May 2023 at an outpatient neurorehabilitation clinic. Individuals with chronic nonfluent aphasia after left middle cerebral artery stroke (>6 months from stroke) were enrolled and randomly assigned to receive either rTMS or sham stimulation combined with 35 hours of M-MAT over 10 days. The primary outcome was the Western Aphasia Battery aphasia quotient (WAB-AQ) measured at 3 weeks and 15 weeks. Intention-to-treat analysis examined treatment effects over time using linear mixed models.
resultsA total of 44 participants were randomized. Forty-three (mean [SD] age, 63.4 [12.3] years; 14 women [32.6%]) completed the intervention. Overall, WAB-AQ scores improved from baseline to 15 weeks regardless of rTMS allocation (mean difference 5.33, 95% CI 2.9-7.8, DISCUSSION: Intensive administration of M-MAT alone improves speech production in patients with chronic poststroke aphasia. Combining 1-Hz rTMS with M-MAT is associated with supplemental improvements in aphasia severity at follow-up. rTMS is a promising candidate as an adjuvant therapy to M-MAT. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov Identifier: NCT04102228. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that in patients with aphasia 6 or more months after a stroke, 1-Hz rTMS combined with intensive M-MAT improves WAB-AQ more than sham stimulation plus M-MAT.
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