Evidence map›Paper›PMID 39999390›Full record

ArticleRetinal cases & brief reports2025

POTASSIUM IODATE RETINOTOXICITY AFTER AN OVERDOSE OF ANTIRADIATION PILLS: A CASE OF APOCALYPTIC RETINOPATHY.

Paul S Bernstein

Abstract readCase Reports
In one paragraph

Article in Retinal cases & brief reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul S BernsteinMoran Eye Center, University of Utah, Salt Lake City, Utah .ORCID 0000-0002-4228-7666

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PAUL STEVEN BERNSTEIN · 2005 to 2026
$14.6M
NEI NIH HHS P30 EY014800Research to Prevent Blindness, National Eye Institute EY014800
6 · The paper itself

Abstract

purposeThe aim of this study was to report a case of severe retinal toxicity after an attempted suicidal overdose of antiradiation pills containing a well-known retinal pigment epithelial toxin, potassium iodate.

methodsClinical examination and multimodal imaging are provided from a clinic visit 11 years after the suicide attempt.

resultsA 42-year-old patient had widespread retinal atrophy in both eyes with near-complete absence of the retinal pigment epithelium and severe retinal thinning. A few remaining areas of preserved photoreceptors provided her with 20/60 and 20/200 vision in her right and left eyes, respectively, with very constricted visual fields.

conclusionDespite being first described over 100 years ago, few cases of iodate retinotoxicity have been reported in the published literature, and most are related to accidental or intentional ingestion of iodate salts used to iodize table salt. This unique case of iodate retinotoxicity secondary to antiradiation tablets highlights the risks of unregulated sale of these agents marketed in the United States as essential components of nuclear apocalypse "go bags" because they have a poor margin of safety and no specific warnings of the risk of permanent blindness with overdosage.

Indexed as

Drug OverdoseIodatesPotassium CompoundsRadiation-Protective AgentsRetinaRetinal DiseasesAdultFemaleHumansSuicide, AttemptedIodatesPotassium Compoundspotassium iodateRadiation-Protective Agents

Identifiers

PMID39999390
PMCPMC11217146

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.