ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
NIR-II Emissive Persistent Neutral π-Radical with Rapid Doublet Internal Conversion for Efficient Cancer Photothermal Theranostics.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Functional matrix engineering enables aggregate-state photophysics in tumor-responsive organic NIR-II phototheranostics.Materials today. Bio · 2026Article
- Analgesic-loaded NIR-II photothermal hydrogel for efficient anti-infection and precise pain management in wounds.Materials today. Bio · 2026Article
- Multifunctional nanoplatforms deciphering immune resistance in bone tumors: cooperative delivery, immune reprogramming and microenvironment remodeling.Journal of nanobiotechnology · 2026Review
- Simple Substitutions into Donor-Acceptor Radicals to Construct Highly Luminescent Radicals and Solvent-Responsive Ionic Radical Polymers.Molecules (Basel, Switzerland) · 2026Article
- Büchner-type ring expansion of aromatic main-group biradicaloids toward phosphorus radical-derived NIR-II photothermal materials.Chemical science · 2025Article
- NIR-II Emissive Persistent Neutral π-Radical with Rapid Doublet Internal Conversion for Efficient Cancer Photothermal Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nanoprobe-Based Near-Infrared II Optical Imaging for Guiding Precision Glioma Therapy.International journal of nanomedicine · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Organic radicals are considered prospective materials for near-infrared (NIR) photothermal applications, however, sustainability remains the major obstacle of recently reported ionic radical photothermal agents. This work achieved robust sustainability on a series of neutral π-radicals through rational design donor (D)-acceptor (A). With efficient doublet internal conversion, 10H-spiro(acridine-9,9'-fluorene) (SFA)-BTM presented strong NIR absorption extended to 1000 nm and efficient non-radiative relaxation. SFA-BTM nanoparticles (NPs) realized comparable NIR-I photothermal conversion efficiency (PCE) and photoacoustic sensitivity. Also, the π-radical NPs displayed NIR-II emission and achieved high-resolution whole-body angiography for the first time by the NIR-II bioimaging. Ultimately, the photothermal capabilities are confirmed in an orthotopic bone tumor model by effective ablation of cancer cells in vitro and inhibition of the deterioration of tumor in vivo. This research offers a new horizon in the conception and development of sustainable organic radicals for effective NIR-II imaging and theranostics applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.