Evidence map›Paper›PMID 39999167›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

pTDP-43 levels correlate with cell type-specific molecular alterations in the prefrontal cortex of

Hsiao-Lin V Wang, Jian-Feng Xiang, Chenyang Yuan, Austin M Veire, Tania F Gendron, Melissa E Murray, Malú G Tansey, Jian Hu, Marla Gearing, Jonathan D Glass and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. pTDP-43 levels correlate with cell type-specific molecular alterations in the prefrontal cortex ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Hsiao-Lin V WangDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.
Jian-Feng XiangDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.
Chenyang YuanDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.
Austin M VeireDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.
Tania F GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.
Melissa E MurrayDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224.ORCID 0000-0001-7379-2545
Malú G TanseyCenter for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32607.ORCID 0000-0002-1719-4708
Jian HuDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.
Marla GearingEmory Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322.
Jonathan D GlassEmory Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-3295-4971
Peng JinDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0001-6137-6659
Victor G CorcesDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0001-5140-4337
Zachary T McEachinDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322.

Funding

Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
Dynamic DNA Modifications in Brain and DiseasesR35NS111602 · NINDS · EMORY UNIVERSITY · PI PENG JIN · 2019 to 2026
$6.5M
Dynamic RNA Modifications in human brain development and autismU01MH116441 · NIMH · EMORY UNIVERSITY · PI JIN, PENG · 2018 to 2022
$4.9M
Nuclear Organization and FunctionR35GM139408 · NIGMS · EMORY UNIVERSITY · PI CORCES, VICTOR G. · 2021 to 2025
$2.5M
Mechanisms of bisphenol A induced epigenomic alterations in the mammalian germlineF32ES031827 · NIEHS · EMORY UNIVERSITY · PI WANG, HSIAO-LIN V. · 2020 to 2022
$225k
NHGRI NIH HHS RM1 HG008935NIEHS NIH HHS F32 ES031827NIGMS NIH HHS R35 GM139408NIMH NIH HHS U01 MH116441NINDS NIH HHS R35 NS111602
6 · The paper itself

Abstract

Repeat expansions in the

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinDNA-Binding ProteinsFrontotemporal DementiaPrefrontal CortexAgedFemaleHumansMaleMicrogliaMiddle AgedNeuronsPhosphorylationC9orf72 ProteinC9orf72 protein, humanDNA-Binding ProteinsTARDBP protein, humanamyotrophic lateral sclerosischromatinepigeneticsfrontotemporal dementianeurodegeneration

Identifiers

PMID39999167
PMCPMC11892677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.