Evidence map›Paper›PMID 39999164›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The RNA-binding protein RBPMS inhibits smooth muscle cell-driven vascular remodeling in atherosclerosis and vascular injury.

Jianlin Du, Xin Yuan, Jiajia Wang, Lujun Zhang, Fangyan Tan, Tianyang Hu, Xingsheng Li, Fan Liu, Haitao Ran, Zhigang Wang and 7 more

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Engineering a serum response factor superactivator of smooth muscle gene expression with a condensate-forming domain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jianlin Du *Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xin Yuan *Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jiajia Wang *Precision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Municipality Clinical Research Center for Geriatrics and Gerontology, Chongqing 400016, China.
Lujun ZhangPrecision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Municipality Clinical Research Center for Geriatrics and Gerontology, Chongqing 400016, China.
Fangyan TanDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Tianyang HuPrecision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Municipality Clinical Research Center for Geriatrics and Gerontology, Chongqing 400016, China.
Xingsheng LiPrecision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Municipality Clinical Research Center for Geriatrics and Gerontology, Chongqing 400016, China.
Fan LiuDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Haitao RanDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhigang WangDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yongyong LiPrecision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Municipality Clinical Research Center for Geriatrics and Gerontology, Chongqing 400016, China.
Yuxing FengDepartment of Rehabilitation and Pain Medicine, The Ninth People's Hospital of Chongqing, Chongqing 400700, China.
N D MelgiriImpactys Foundation for Biomedical Research, San Diego, CA 92121.ORCID 0009-0007-9193-3031
Yu CaoDepartment of Cardiothoracic Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 363880, China.
Lihong JiangCenter for Translational Research in Clinical Medicine, School of Medicine, Kunming University of Science and Technology, Kunming 650500, China.
Rongzhong HuangPrecision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Municipality Clinical Research Center for Geriatrics and Gerontology, Chongqing 400016, China.
Yang SunDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0002-5002-898X

Funding

MOST | National Natural Science Foundation of China (NSFC) 81871369MOST | National Natural Science Foundation of China (NSFC) 81960095
6 · The paper itself

Abstract

Atherosclerosis and vessel wall trauma induce vascular smooth muscle cell (VSMC) phenotypic modulation, leading to plaque cap growth and postintervention restenosis. Our systems biology approach identified RNA binding protein, mRNA processing factor (

Indexed as

AtherosclerosisMuscle, Smooth, VascularMyocytes, Smooth MuscleRNA-Binding ProteinsVascular RemodelingVascular System InjuriesAnimalsApolipoproteins ECell DifferentiationHumansMaleMiceMyocardinNuclear ProteinsTrans-ActivatorsApolipoproteins EMyocardinNuclear ProteinsRNA-Binding ProteinsTrans-ActivatorsatherosclerosisMYOCDRBPMSsmooth muscle cellvascular injury

Identifiers

PMID39999164
PMCPMC11892686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.