Evidence map›Paper›PMID 39998810›Full record

ArticleBreast cancer (Tokyo, Japan)2025

Contemporaneous changes in cytokines and cognitive function during chemotherapy in patients with breast cancer: a prospective follow-up study.

Shu-I Wu, Vincent Chin-Hung Chen, Yen-Hsuan Hsu, Bor-Show Tzang, Robert Stewart, Chin-Kuo Lin

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Article in Breast cancer (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shu-I Wu *Department of Medicine, Mackay Medical College, Taipei, Taiwan. t140@mmc.edu.tw.ORCID http://orcid.org/0000-0002-8461-5613
Vincent Chin-Hung Chen *Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Chiayi County, Taiwan.
Yen-Hsuan HsuDepartment of Psychology, National Chung Cheng University, Chiayi County, 62102, Taiwan.
Bor-Show TzangDepartment of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan.
Robert StewartKing's College London (Institute of Psychiatry, Psychology and Neuroscience), London, UK.
Chin-Kuo LinDivision of Pulmonary Infection and Critical Care, Department of Pulmonary and Critical Care Medicine Chang Gung Memorial Hospital, Chiayi, Taiwan.

Funding

Cancer Mind-Body Interaction Integrated Research Program, Chiayi Chang Gung Hospital CORPG6G0103Department of Medical Research, Mackay Memorial Hospital MMH-109112Department of Medical Research, Mackay Memorial Hospital MMH-110-110Department of Medical Research, Mackay Memorial Hospital MMH-113-19UKRI - Medical Research Council through the DATAMIND HDR UK Mental Health Data Hub MRC reference: MR/W014386
6 · The paper itself

Abstract

backgroundThis study investigated fluctuations in levels of chosen cytokines among patients with breast cancer before to after chemotherapy. Contemporaneous changes in cognitive function were examined.

methodsAdult patients with breast cancer stages I-III without brain metastasis were invited to participate in this longitudinal follow-up study. A multidimensional neuropsychological examination was administered at two timepoints evaluating multiple subjective and objective cognitive domains, depression, anxiety, or fatigue before and at least 3 months after chemotherapy, and baseline demographic information. Cytokine levels were taken at the same times. Stepwise multivariate Generalized Linear Mixed Model was used to examine changes in cytokines and associations with changes in cognitive function.

resultsOver a mean interval of 10.46 months, Event-based prospective memory (p<0.001), Word list immediate (p<0.001) or delayed recall (p = 0.024), and self- perceived cognitive impairment (p = 0.026) were significantly improved following chemotherapy. Higher levels of IFNγ and worse performance on the Color Trails Test Part 1, inverse associations of IFNγ or IL-12p70 with Block Design, and TNFα with Digit Symbol Substitution were found, but no significant time effects were noted. However, significant group and time effects were only observed in IL-2 and IL-12p70 with improvements in Event-based prospective memory. That is, from baseline to follow-up, each increase in log values of IL-12p70 and IL-2 were associated with 2.18 (SE = 0.65, p = 0.001) and 2.16 (0.68, p = 0.002) points of increase in Event-based prospective memory. No significant effects were detected for other cytokines or cognitive tests.

conclusionImprovements in Event-based prospective memory were positively associated with contemporaneous changes in IL-2 and IL-12p70. Our finding may not only reduce BC patients' concerns about chemotherapy-related cognitive adverse effects, but also demonstrates the possible needs for further replications and investigations on interactions of systemic cytokines, inflammation, and cognitive functions associated with cancer and chemotherapy.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCognitionCytokinesAdultAgedCognitive DysfunctionFemaleFollow-Up StudiesHumansLongitudinal StudiesMiddle AgedNeuropsychological TestsProspective StudiesCytokinesBreast cancerCancer-related cognitive impairmentChemotherapyCognitive functionCytokinesNeuropsychological tests

Identifiers

PMID39998810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.