ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2025
Determination of circulating tumor cells by surface-enhanced Raman scattering based on molecularly imprinted polymers doped with silver nanoparticles.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Nanozymes: bridging nanoscale characteristics and catalytic mechanisms for advanced biomedical applications.Journal of enzyme inhibition and medicinal chemistry · 2026Review
- Analytical applications of molecularly imprinted polymers: a personal view.Analytical and bioanalytical chemistry · 2026Review
- Beyond ensemble averages: single-entity approaches for complex systems.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
- Research progress of surface-enhanced Raman scattering technology in tumor liquid biopsy.Frontiers in molecular biosciences · 2026Review
- A Review of High-Sensitivity SERS-Active Photonic Crystal Fiber Sensors for Chemical and Biological Detection.Sensors (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapid and simple detection of circulating tumor cells (CTCs) can help with early diagnosis of tumor diseases and assist clinical judgment of tumor disease development status and prognosis. An important alteration in cancer progression is a significant increase in sialic acid (SA) levels, making sialic acid one of an interesting biomarker for cancer type diversity. Here, novel SERS nano-biosensors were fabricated employing molecularly imprinted polymers (MIPs) particles loaded with Ag nanoparticles (AgNPs) to form high affinity toward sialic acid on CTCs. In this work, the glycol-specific MIPs are produced using precipitation polymerization. The nanocomposite was characterized by Fourier transform infrared spectroscopy (FTIR), zeta potential, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Consequently, CTC can be rapidly detected in mouse blood in a specific and sensitive manner, as low as 1 cells/ml. In addition, a good linear relationship was observed between CTC concentration and signal intensity (R
Indexed as
Identifiers
39998807What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.