Evidence map›Paper›PMID 39998653›Full record

ArticleApplied microbiology and biotechnology2025

Metabolomic and genomic insights into Micromonospora carbonacea subsp. caeruleus for anti-colorectal compound.

Tepakorn Kongsaya, Nuttaporn Emthomya, Chananan Ngamcharungchit, Aiyada Aroonsri, Umaporn Uawisetwathana, Thapanee Pruksatrakul, Jirayut Euanorasetr, Bungonsiri Intra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tepakorn KongsayaDepartment of Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Nuttaporn EmthomyaDepartment of Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Chananan NgamcharungchitDepartment of Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Aiyada AroonsriNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand.
Umaporn UawisetwathanaNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand.
Thapanee PruksatrakulNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand.
Jirayut EuanorasetrLaboratory of Biotechnological Research for Energy and Bioactive Compounds, Department of Microbiology, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Bungonsiri IntraDepartment of Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand. Bungonsiri.int@mahidol.edu.ORCID http://orcid.org/0000-0002-8408-4197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a predominant contributor to global morbidity and mortality, affecting populations worldwide. Marine Micromonospora species have been identified as significant sources of anticancer compounds. This work aimed to perform a polyphasic approach of isolated strain and conduct comparative metabolomic and genomic analyses to identify compounds with anticancer activity. The study utilized a polyphasic approach on isolated strains for anticancer compound identification. Taxonomic analysis of strain 2MTK254 revealed unique pigment and fatty acid patterns, designating it as a novel Micromonospora carbonacea subsp. caeruleus. Its crude extract displayed significant anti-colorectal activity (66.03% inhibition). Molecular network analysis classified metabolites into eight classes, highlighting a polycyclic tetramate macrolactams (PTMs) compound (P1, C

Indexed as

Antineoplastic AgentsMicromonosporaBiosynthetic PathwaysColorectal NeoplasmsFatty AcidsGenomicsHCT116 CellsHumansMetabolomicsMultigene FamilyPhylogenyAntineoplastic AgentsFatty AcidsAnticancer compoundGenome miningMarine MicromonosporaMolecular networkingPolyphasic taxonomy

Identifiers

PMID39998653
PMCPMC11861244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.