Evidence map›Paper›PMID 39998648›Full record

ArticleActa diabetologica2025

Impact of glucose fluctuations on white matter hyperintensity in type 2 diabetic patients.

Xin Chen, Wanbing Qian, Xin Wang, Jianrong Yao, Yazhou Ma, Xuegan Lian

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Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xin Chen *Department of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, China.
Wanbing Qian *Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Xin WangDepartment of Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Jianrong YaoDepartment of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, China.
Yazhou MaDepartment of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, China.
Xuegan LianDepartment of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, China. lxgneuro@126.com.ORCID http://orcid.org/0000-0001-5790-616X

Funding

The Third Batch of Science and Technology Program of Changzhou CJ20230052
6 · The paper itself

Abstract

objectivesThe mean amplitude of glycemic excursion (MAGE) is widely recognized for representing glucose fluctuation extent, its implications in cerebral small vessel disease remain unclear. This study aims to investigate the correlation between MAGE and white matter hyperintensity (WMH). MATERIALS AND

methodsThis cross-sectional study, spanning from March 2021 to October 2022, included 212 type 2 diabetic patients aged between 50 and 80. Participants underwent MRI scans and continuous glucose monitoring. Clinical and laboratory data were compiled for analysis. WMH volumes were evaluated using both the Fazekas visual rating scale and a quantitative approach. Based on Fazekas scores, patients were categorized into low level of WMH (L-WMH, n = 88) and high level of WMH (H-WMH, n = 124) groups.

resultsMAGE levels were significantly higher in the H-WMH group compared to the L-WMH group. Time below range [TBR

conclusionMAGE and hypoglycemia exhibit independent associations with WMH in diabetic patients. Moreover, hypoglycemia may indirectly influence WMH progression through the augmentation of glucose fluctuations.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2White MatterAgedAged, 80 and overCross-Sectional StudiesFemaleHumansHypoglycemiaMagnetic Resonance ImagingMaleMiddle AgedBlood GlucoseDiabetes mellitusGlucose fluctuationsHypoglycemiaMean amplitude of glycemic excursionWhite matter hyperintensity

Identifiers

PMID39998648

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