ArticlePediatric nephrology (Berlin, Germany)2025
Acute kidney injury induced by snakebites in pediatric patients.
Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Snake envenomation and acute kidney injury: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Development of a Highly Specific Immunoassay for Residual Venom Detection of the Toxic JellyfishToxics · 2025Article
- Procoagulant Effects ofInternational journal of molecular sciences · 2025Article
- Masked peril: acute kidney injury in snakebite victims.Pediatric nephrology (Berlin, Germany) · 2025Article
- Gastrointestinal features of pediatric iga vasculitis and their association with renal complications: an observational study.European journal of pediatrics · 2025Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSnakebites are a significant public health problem worldwide, with a global prevalence estimated 2.7 million envenomings and 81,000 to 138,000 deaths annually. Acute kidney injury (AKI) is the main complication of snakebites, most associated with the Bothrops species in South and Central America. However, the reported incidence of AKI induced is not well established in the pediatric population. We aimed to evaluate the frequency of AKI and its risk factors in child victims of Bothrops snakebites.
methodsChildren aged 0-18 years who were victims of Bothrops snakebites in Santa Catarina, Brazil, from 2014 to 2020 were retrospectively enrolled and evaluated for AKI using the Kidney Disease Improving Global Outcomes (KDIGO) definition and staging.
resultsA total of 463 cases of bothropic accidents were studied. Of those, 15.9% (n = 74) of patients developed AKI, 94.5% (n = 70) being classified in stage I. The most affected age group was 8-12 years old (28.3%). Medical care occurred in less than 3 h in 82.6% of cases. Pain (93.3%) and edema (93.5%) were the main symptoms observed. Complications were as follows: secondary infection (10.7%), compartment syndrome (0.8%), and skin necrosis at the site of the bite (1.7%). In contrast to children who did not develop AKI, children who developed AKI had leukocytosis (p = 0.017), alteration of urinalysis (p = 0.012), severe initial classification (p < 0.001), compartment syndrome, and local necrosis (p < 0.001).
conclusionThe frequency of AKI was 15.9%. Risk factors for AKI included severe initial classification, presence of leukocytosis, changes in urinalysis, compartment syndrome, and local necrosis.
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