SynthesisClinical rheumatology2025
Standardized efficacy and safety evaluation of fulranumab for osteoarthritis.
Synthesis in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Targeting Inflammatory Pathways in Chronic Low Back Pain: Opportunities for Novel Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
To assess the impact of fulranumab intervention on osteoarthritis (OA) patients and offer a clinically relevant, evidence-based guide for fulranumab intervention in patients with OA. RevMan 5.4 was utilized to conduct a meta-analysis after relevant data on randomized controlled trials of therapeutic interventions for patients with OA were gathered from literature databases such PubMed, Embase, Web of Science, and the Cochrane Library. A total of 8 randomized controlled studies were included, including 1927 patients with osteoarthritis. Meta-analysis showed that compared with the control group, fulranumab intervention had more gains, (MD = - 6.76, 95% CI [- 13.37 to - 0.15]; Z = 2.00; P = 0.05), WOMAC pain (3 mg, week 17) (MD = - 0.78, 95% CI [- 1.10 to - 0.46]; Z = 4.79; P < 0.00001), BPI-SF: pain intensity score (1 mg, week 12) (MD = - 4.29, 95% CI [- 9.15 to 0.57]; Z = 1.73; P = 0.08), and BPI-SF: pain interference (1 mg, week 12) (MD = - 5.98, 95% CI [- 6.64 to - 5.32]; Z = 17.84; P < 0.00001). When used in conjunction with nerve growth factor (NGF) therapy, fulranumab offers an efficient osteoarthritis therapeutic alternative. Patients with osteoarthritis can have a considerable improvement in their WOMAC, short pain inventory, patient global assessment scores, clinical symptoms, and overall quality of life. One possible therapeutic approach for the condition might be to use fulranumab.
Indexed as
Identifiers
39998601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.