Evidence map›Paper›PMID 39998476›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Clinical and Biological Features of a Thickened Basement Membrane Zone in Asthma.

Clarus Leung, Monica Tang, Walter E Finkbeiner, Mats W Johansson, Loren C Denlinger, Nizar N Jarjour, Mario Castro, Kaharu Sumino, Serpil C Erzurum, Suzy A Comhair and 12 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Developments in Mast Cell Research.The Journal of allergy and clinical immunology · 2026
    Review
  3. Article
  4. Article
  5. Baseline Membrane Thickness in Asthma: Where Type-2 Inflammation Meets Remodeling?American journal of respiratory and critical care medicine · 2025
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Clarus LeungDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.ORCID 0000-0003-3515-7537
Monica TangDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.ORCID 0000-0001-8847-5817
Walter E FinkbeinerDepartment of Pathology, University of California, San Francisco, San Francisco, California.
Mats W JohanssonDivision of Allergy, Pulmonary, and Critical Care Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Loren C DenlingerDivision of Allergy, Pulmonary, and Critical Care Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Nizar N JarjourDivision of Allergy, Pulmonary, and Critical Care Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Mario CastroDivision of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, University of Kansas, Kansas City, Kansas.ORCID 0000-0001-6328-8994
Kaharu SuminoDivision of Pulmonary and Critical Care Medicine, Washington University in St. Louis, St. Louis, Missouri.
Serpil C ErzurumCleveland Clinic, Cleveland, Ohio.
Suzy A ComhairCleveland Clinic, Cleveland, Ohio.
Wendy C MooreSection for Pulmonary, Critical Care, Allergy and Immunology, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Annette T HastieSection for Pulmonary, Critical Care, Allergy and Immunology, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina.ORCID 0000-0001-6607-7797
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0001-9515-5731
Elliot IsraelDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Brenda R PhillipsDivision of Biostatistics and Bioinformatics, Penn State College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania.
David T MaugerDivision of Biostatistics and Bioinformatics, Penn State College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania.
Sally E WenzelDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania; and.ORCID 0000-0002-4242-0164
Stephanie ChristensonDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.
Max A SeiboldCenter for Genes, Environment, and Health, National Jewish Health, Denver, Colorado.
Nathan JacksonCenter for Genes, Environment, and Health, National Jewish Health, Denver, Colorado.
Prescott G WoodruffDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.
John V FahyDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.

Funding

RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 2012 to 2023
$23.3M
Rapid saliva antigen test for SARS-CoV-2 detectionU01HL146002 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ARONICA, MARK A, CASTRO, MARIO · 2019 to 2023
$17.3M
Protein carbohydrate interactions in the pathophysiology of asthma exacerbationsR01HL080414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John V Fahy · 2005 to 2026
$9.2M
Clinical Coordinating Center for the Severe Asthma Research Program (SARP)U10HL109086 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAUGER, DAVID T. · 2011 to 2017
$8.1M
AMSA: ALXR/FBR Mediated Signaling in Severe AsthmaU10HL109172 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ISRAEL, ELLIOT, LEVY, BRUCE D · 2011 to 2016
$4.2M
Clinical and Molecular Phenotypes of Severe AsthmaU10HL109146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2011 to 2016
$4.0M
Implications and Stability of Clinical and Molecular Phenotypes of Severe AsthmaU10HL109152 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WENZEL, SALLY E · 2011 to 2016
$3.9M
Stability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9M
Severe Asthma Research Program (SARP)-Washington UniversityU10HL109257 · NHLBI · WASHINGTON UNIVERSITY · PI CASTRO, MARIO · 2011 to 2016
$3.8M
Longitudinal Phenomics and Genetics of Severe AsthmaU10HL109164 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLEECKER, EUGENE ROLAND, MEYERS, DEBORAH A. · 2011 to 2016
$3.8M
Evaluating the Impact of Metabolic Dysfunction on Asthma Pathology and PhysiologyR01HL164787 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2022 to 2025
$2.6M
AstraZenecaBoehringer IngelheimGenentechGlaxoSmithKlineNCATS NIH HHS UL1 TR002366NHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL080414NHLBI NIH HHS R01 HL164787NHLBI NIH HHS U01 HL146002NHLBI NIH HHS U10 HL109086NHLBI NIH HHS U10 HL109146NHLBI NIH HHS U10 HL109152NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U10 HL109168NHLBI NIH HHS U10 HL109172NHLBI NIH HHS U10 HL109257NIH HHS U01HL146002NIH HHS U10 HL109086NIH HHS U10 HL109146NIH HHS U10 HL109152NIH HHS U10 HL109164NIH HHS U10 HL109168NIH HHS U10 HL109257NIH HHS UL1TR002366Sanofi-Genzyme-RegeneronTeva Pharmaceutical Industries
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AsthmaBasement MembraneAdultBiopsyCase-Control StudiesFemaleHumansImmunoglobulin EMaleMast CellsMiddle AgedSpirometryImmunoglobulin Eairway epitheliumasthmabasement membrane zoneimmunoglobulin E

Identifiers

PMID39998476
PMCPMC12091020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.