Evidence map›Paper›PMID 39998374›Full record

ArticleRadiology2025

Phase-resolved Functional Lung MRI Reveals Distinct Lung Perfusion Phenotype in Children and Adolescents with Post-COVID-19 Condition.

Gesa H Pöhler, Andreas Voskrebenzev, Marc-Luca Heinze, Valentina Skeries, Filip Klimeš, Julian Glandorf, Jan Eckstein, Nigar Babazade, Marius Wernz, Alexander Pfeil and 5 more

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Article in Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Gesa H PöhlerFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0002-3994-1495
Andreas VoskrebenzevFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0001-5699-1841
Marc-Luca HeinzeFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0009-0004-3939-3590
Valentina SkeriesFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0009-0000-8070-3766
Filip KlimešFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0003-2715-0757
Julian GlandorfFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0003-1927-9876
Jan EcksteinFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).
Nigar BabazadeFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).
Marius WernzFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0009-0003-0452-8574
Alexander PfeilFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0002-2709-6685
Gesine HansenFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0001-5185-9454
Frank K WackerFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0002-6285-8403
Jens Vogel-ClaussenFrom the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0001-5595-6948
Martin Wetzke *From the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).
Diane Miriam Renz *From the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany (G.H.P., A.V., M.L.H., F.K., J.G., J.E., N.B., M. Wernz, F.K.W., J.V.C., D.M.R.); German Center for Lung Research, Partner Site Hannover, BREATH, Hannover, Germany (G.H.P., A.V., F.K., J.G., M. Wernz, J.V.C.); Clinic of Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Hannover, Germany (V.S., G.H., M. Wetzke); and Department of Internal Medicine III, University Hospital Jena, Jena, Germany (A.P.).ORCID 0000-0002-3702-356X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Although measurable organic dysfunctions are frequently absent in pediatric patients with post-COVID-19 condition (PCC), this condition adversely affects quality of life. Free-breathing phase-resolved functional lung (PREFUL) MRI may be useful for assessing lung function in pediatric patients with PCC. Purpose To detect lung changes in children and adolescents with PCC compared with healthy control participants using PREFUL MRI. Materials and Methods In this single-center, prospective, cross-sectional study conducted between April 2022 and April 2023, children and adolescents (age ≤17 years) with PCC and age- and sex-matched healthy participants underwent MRI. Subgroup analysis was performed in participants with PCC who had cardiopulmonary symptoms. Regional ventilation, flow-volume loop correlation metric (FVL-CM), quantified perfusion, ventilation and perfusion defect percentages, and ventilation-perfusion ratios were compared between participants with PCC and controls using the Wilcoxon signed rank test. Correlation of imaging parameters with spirometry, heart rate, respiratory rate, and Bell score (fatigue severity) in participants with PCC was assessed using the Spearman rank correlation coefficient. Results The final study sample included 54 participants (27 participants with PCC and 27 matched control participants; median age, 15 years [IQR, 11-17 years]; 14 male participants). Twenty-one participants had cardiopulmonary symptoms. Participants with PCC had lower regional ventilation (median, 0.2 mL/mL [IQR, 0.1-0.2 mL/mL] vs 0.2 mL/mL [IQR, 0.2-0.2 mL/mL];

Indexed as

COVID-19LungMagnetic Resonance ImagingAdolescentChildCross-Sectional StudiesFemaleHumansMalePhenotypeProspective Studies

Identifiers

PMID39998374
PMCPMC11868851

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