Evidence map›Paper›PMID 39998315›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Biological Reinforced Concrete for Cartilage Repair With 3D Printing.

Yuewei Chen, Tao Fu, Zhongfei Zou, Yanming Liu, Jianguo Zhu, Binhong Teng, Ke Yao, Haibin Li, Jiachun Li, Zhijian Xie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Biological Reinforced Concrete for Cartilage Repair With 3D Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuewei ChenSchool of Mechanical Engineering, Guizhou University, Guiyang, 550025, China.
Tao FuDepartment of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, School of Stomatology and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, Zhejiang, 310000, China.
Zhongfei ZouSchool of Mechanical Engineering, Guizhou Institute of Technology, Guiyang, 550003, China.
Yanming LiuDepartment of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, School of Stomatology and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, Zhejiang, 310000, China.
Jianguo ZhuDepartment of Urology, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou University, Guiyang, Guizhou, 550002, China.
Binhong TengDepartment of Orthodontics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Ke YaoState Key Laboratory of Fluid Power and Mechatronic Systems & Liangzhu Laboratory, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Haibin LiState Key Laboratory of Fluid Power and Mechatronic Systems & Liangzhu Laboratory, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Jiachun LiSchool of Mechanical Engineering, Guizhou University, Guiyang, 550025, China.
Zhijian XieStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.
Yong HeState Key Laboratory of Fluid Power and Mechatronic Systems & Liangzhu Laboratory, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.ORCID https://orcid.org/0000-0002-9099-0831

Funding

Application Verification in Universities BX2024B033Key R&D Program of Zhejiang 2024SSYS0027Medical Healthy Scientific Technology Project of Zhejiang Province 2022511252National Natural Science Foundation of China 52235007National Natural Science Foundation of China 52325504National Natural Science Foundation of China 52465035National Natural Science Foundation of China T2121004Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems GZKF-202404Science and Technology Planning Project of Guizhou Province [2022]YB 196Science and Technology Planning Project of Guizhou Province LH[2024]ZD 020Science and Technology Planning Project of Guizhou Province ZK[2024] 510Science and Technology Planning Project of Guizhou Province ZK[2025] 615Zhejiang Province Natural Science Foundation of China LQ23H090012
6 · The paper itself

Abstract

The development of biomimetic cartilage constructs (BCCs) with natural extracellular matrix (ECM) microenvironments and topological cues to accelerate the reconstruction of natural articular cartilage (NAC) after injury is challenging due to its complex structure, low cellular content, and less vascularity. Inspired by concrete rebar structure, a biomimetic cartilage named "biological reinforced concrete" is fabricated, with collagen fiber orientation transitioning from parallel to perpendicular, replicating the ECM microenvironments and complex construct of NAC. 3D-printed ultrafine fiber networks (UFNs) served as a degradable "biorebars", while a hybrid biohydrogel acted as "biocement". The stem cells are utilized as "bioactive aggregates". The biocement is developed by combining and screening various biohydrogels to mimic an ECM microenvironment conducive to the formation of NAC. By adjusting the fiber scale and spacing of the UFNs, the mechanical properties of the biomimetic cartilages are controlled to resemble those of NAC. Additionally, the UFNs guided the directed growth of cells and the orderly secretion of ECM. Subsequently, the developed BCCs are implanted into an osteochondral defect, and after 4 months, they successfully reconstructed the complex structure of cartilage with mechanical properties closely resembling those of NAC. The biological reinforced concrete offers a customizable and universal strategy for tissue regeneration.

Indexed as

Cartilage, ArticularPrinting, Three-DimensionalTissue EngineeringAnimalsBiomimetic MaterialsExtracellular MatrixHumansTissue Scaffolds3D‐printed ultrafine fiber networksbiohydrogelsbiological reinforced concretecartilageextracellular matrix

Identifiers

PMID39998315
PMCPMC12021066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.