Evidence map›Paper›PMID 39998294›Full record

ArticleAntimicrobial agents and chemotherapy2025

The impact of ibezapolstat and other

Trenton M Wolfe, Jinhee Jo, Nick V Pinkham, Kevin W Garey, Seth T Walk

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Phage Therapy in Gastrointestinal Diseases: Current Status and Challenges.International journal of molecular sciences · 2026
    Review
  5. Newer Therapeutics to Selectively KillInfectious disease reports · 2026
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Trenton M Wolfe *Department of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA.ORCID 0009-0002-8289-5970
Jinhee Jo *Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID 0000-0002-4772-188X
Nick V PinkhamDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA.
Kevin W GareyDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID 0000-0003-2063-7503
Seth T WalkDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, Montana, USA.ORCID 0000-0001-6891-8537

Funding

NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Diversity Supplement: Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infectionR01AI139261 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Kevin W Garey, Julian G Hurdle · 2018 to 2026
$6.0M
Mechanisms of arsenic detoxification by the human microbiomeR01CA215784 · NCI · MONTANA STATE UNIVERSITY - BOZEMAN · PI Seth T Walk, Qian Wang · 2017 to 2026
$2.7M
Acurx Pharmaceuticals, IncHHS | NIH | National Cancer Institute (NCI) R01CA215784HHS | NIH | National Center for Advancing Translational Sciences (NCATS) 5TL1TR002318-08HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI139261NCATS NIH HHS TL1 TR002318NCI NIH HHS R01 CA215784NIAID NIH HHS R01 AI139261
6 · The paper itself

Abstract

Ibezapolstat (IBZ) is a competitive inhibitor of the bacterial Pol IIIC enzyme in clinical development for the treatment of

Indexed as

Anti-Bacterial AgentsClostridioides difficileClostridium InfectionsGastrointestinal MicrobiomeAnimalsFecal Microbiota TransplantationFecesFidaxomicinHumansMetronidazoleMicePurine NucleosidesRNA, Ribosomal, 16SVancomycinAnti-Bacterial AgentsFidaxomicinIbezapolstatMetronidazolePurine NucleosidesRNA, Ribosomal, 16SVancomycinClostridioides difficile infectionfidaxomicingerm-free mouseibezapolstatmicrobiome

Identifiers

PMID39998294
PMCPMC11963539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.