ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2025
The Nun Study: Insights from 30 years of aging and dementia research.
Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Choroid plexus volume in pathology-confirmed Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2026Article
- Alzheimer neuropathological change, α-synuclein and transactive response DNA-binding protein of 43 kDa expression in children and young adult brains from forensic autopsies: Value for early measurement of abnormal protein expression prevalence in neurodegenerative diseases.Journal of neuropathology and experimental neurology · 2026Article
- Modeling small vessel disease burden and vascular dementia likelihood from NACC data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Aspects of Religious Life as Determinants of the Subjective Health Assessment of Religious Sisters: The Role of Prayer, Community, and Daily Practices.Healthcare (Basel, Switzerland) · 2026Article
- Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer's disease.Molecular neurodegeneration advances · 2026Article
- The Nun Study: Insights from 30 years of aging and dementia research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Clinical, social, molecular, and genetic predictors of cognitive resilience in long-living adults without dementia.Frontiers in dementia · 2025Article
- Brain banking for research: can we achieve efficient banking?Frontiers in neurologyArticle
- Detecting CSF-validated Alzheimer's disease from spontaneous speech in German: an interpretable end-to-end machine-learning framework.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
The Nun Study is an iconic longitudinal study of aging and dementia on a cohort of 678 Catholic nuns from the School Sisters of Notre Dame. Participants consented to undergoing annual neuropsychological assessments, allowing researchers access to convent archives and medical records and post mortem brain donation. This study investigated the associations between epidemiological factors, cognitive function, and brain pathology. By examining published literature that reports on or utilizes Nun Study data, we provide an overview of its methodology and key findings, emphasizing its significant contributions to understanding cognitive impairment and related neuropathologies. Seminal findings on early-life factors affecting cognitive health, clinicopathological correlations, and apparent resistance and resilience to neuropathology are discussed. Decades of Nun Study research have made critical contributions to our understanding of Alzheimer's disease and related dementias and highlight continuing objectives for future research. HIGHLIGHTS: The uniform lifestyles of participants minimized potential confounds of the study. Early-life cognitive ability influenced late-life cognitive outcomes. Some participants with AD pathology did not exhibit dementia. Neuropathological comorbidities were common and increased the risk of dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.