Evidence map›Paper›PMID 39998264›Full record

ArticlemBio2025

Essential genes encoded by the mating-type locus of the human fungal pathogen

Zhuyun Bian, Ziyan Xu, Anushka Peer, Yeseul Choi, Shelby J Priest, Konstantina Akritidou, Ananya Dasgupta, Tim A Dahlmann, Ulrich Kück, Minou Nowrousian and 3 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Meiosis-specific genes play roles in ploidy reduction inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Stress-responsive roles of thebioRxiv : the preprint server for biology · 2026
    Article
  4. Unisexual reproduction in the global human fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Meiosis-specific genes play roles in ploidy reduction inbioRxiv : the preprint server for biology · 2025
    Article
  7. Unisexual reproduction in the global human fungal pathogenbioRxiv : the preprint server for biology · 2025
    Article
  8. Tracing the evolution and genomic dynamics of mating-type loci inbioRxiv : the preprint server for biology · 2025
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Zhuyun BianDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0002-4320-8296
Ziyan XuDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Anushka PeerDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Yeseul ChoiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0002-9369-902X
Shelby J PriestDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
Konstantina AkritidouDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0009-0009-7223-829X
Ananya DasguptaDepartment of Biology, Texas A&M University, College Station, Texas, USA.
Tim A DahlmannAllgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Bochum, Germany.ORCID 0000-0001-8978-884X
Ulrich KückAllgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Bochum, Germany.ORCID 0000-0002-2998-8230
Minou NowrousianLehrstuhl für Molekulare und Zelluläre Botanik, Ruhr-Universität Bochum, Bochum, Germany.ORCID 0000-0003-0075-6695
Matthew S SachsDepartment of Biology, Texas A&M University, College Station, Texas, USA.ORCID 0000-0001-9891-9223
Sheng SunDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0002-2895-1153
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0001-6369-5995

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
The Genetic Basis of Virulence in Cryptococcus NeoformansR01AI133654 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN, Paul Mitaari Magwene · 2017 to 2026
$4.7M
Determining genetic signatures of the cryptococcal response to Zoloft by an integrated approach combining transcriptome, translatome and genetic screensR21AI138158 · NIAID · TEXAS A&M UNIVERSITY · PI LIN, XIAORONG, SACHS, MATTHEW STEVEN · 2018 to 2019
$395k
Deutsche Forschungsgemeinschaft (DFG) KU 517/15-1Deutsche Forschungsgemeinschaft (DFG) NO407/7-2HHS | National Institutes of Health (NIH) AI138158HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI039115-27HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI050113-20HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI133654-07NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI133654NIAID NIH HHS R21 AI138158NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

Fungal sexual reproduction is controlled by the mating-type (

Indexed as

Cryptococcus neoformansGenes, EssentialGenes, Mating Type, FungalAllelesAnimalsCryptococcosisFungal ProteinsHumansMiceSpores, FungalVirulenceFungal ProteinsCryptococcus neoformansessential genesmating-type locusmolecular geneticspathogenicity

Identifiers

PMID39998264
PMCPMC11980393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.