Evidence map›Paper›PMID 39998257›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge-Like Framework and Cell Guidance.

Si Meng, Nihuan Wu, Jie Fang, Yidan Yu, Xin Tang, Yihan Wang, Xiaokang Deng, Cheng Qi, Tiantian Kong, Tengda Ding and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Si MengCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Nihuan WuDepartment of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Jie FangDepartment of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong, 518000, China.ORCID https://orcid.org/0000-0002-9666-9504
Yidan YuCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Xin TangCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Yihan WangDepartment of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Xiaokang DengCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Cheng QiGuangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering, College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Tiantian KongDepartment of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Tengda DingCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, 518000, China.
Zhou LiuCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, 518000, China.ORCID https://orcid.org/0000-0002-1777-8738

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515110246Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515011827National Natural Science Foundation of China 22078197National Natural Science Foundation of China 22308219National Natural Science Foundation of China 22322808National Natural Science Foundation of China 52172283Natural Science Foundation of Guangdong Province 2021A1515012506Shenzhen Science and Technology Innovation Program 20220810120421001Shenzhen Science and Technology Innovation Program JCYJ20220818095801003Shenzhen Science and Technology Innovation Program RCYX20221008092902010
6 · The paper itself

Abstract

Engineering hollow fibers with precise surface microstructures is challenging; yet, essential for guiding cells alignment and ensuring proper vascular tissue function. Inspired by Euplectella sponges, a novel strategy to engineer biomimetic hollow fibers with spiral surface microstructures is developed. Using oxidized bacterial cellulose, bacterial cellulose, and polydopamine, a "brick-and-mortar" scaffold is created through precise shear control during microfluidic coaxial spinning. The scaffold mimics natural extracellular matrices, providing mechanical stability and supporting cell growth. In vitro studies show successful co-culture of endothelial cells (ECs) and smooth muscle cells (SMCs), with SMCs aligning along spiral surface microstructures and ECs forming a confluent inner layer. In vivo implantation confirms biocompatibility, biodegradability, and low immunogenicity. This Euplectella-inspired scaffold presents a promising approach for vascular tissue engineering and regenerative medicine.

Indexed as

Biomimetic MaterialsBiomimeticsPoriferaTissue EngineeringTissue ScaffoldsAnimalsCoculture TechniquesEndothelial CellsHumansMyocytes, Smooth Musclebio‐inspiredcellulosesfiberscaffoldstissue engineering

Identifiers

PMID39998257
PMCPMC12021052

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.