Evidence map›Paper›PMID 39998252›Full record

ArticlemBio2025

HIV-1 Gag-protease-driven replicative capacity influences T-cell metabolism, cytokine induction, and viral cell-to-cell spread.

Omolara O Baiyegunhi, Kensane Mthembu, Ann-Kathrin Reuschl, Doty Ojwach, Omotayo Farinre, Murunwa Maimela, Sheila Balinda, Matt Price, Madeleine J Bunders, Marcus Altfeld and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Omolara O BaiyegunhiAfrica Health Research Institute, Durban, South Africa.ORCID 0000-0001-8361-5534
Kensane MthembuAfrica Health Research Institute, Durban, South Africa.
Ann-Kathrin ReuschlDivision of Infection and Immunity, University College London, London, United Kingdom.
Doty OjwachHIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Omotayo FarinreHIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Murunwa MaimelaAfrica Health Research Institute, Durban, South Africa.
Sheila BalindaMedical Research Council, UVRI & LSTHM Uganda Research Unit, Entebbe, Uganda.
Matt PriceDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Madeleine J BundersDivision of Regenerative Medicine and Immunology, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marcus AltfeldResearch Department Virus Immunology, Leibniz Institute of Virology, Hamburg, Germany.
Clare JollyDivision of Infection and Immunity, University College London, London, United Kingdom.ORCID 0000-0002-4603-2281
Jaclyn MannHIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Thumbi Ndung'uAfrica Health Research Institute, Durban, South Africa.ORCID 0000-0003-2962-3992

Funding

International Traineeships in AIDS Prevention Studies (ITAPS)R25MH123256 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTINA P LINDAN · 2020 to 2026
$1.8M
Deutsche Forschungsgemeinschaft (DFG) BU 3630/2-1, AL 1043/8Gates Foundation INV-033558International AIDS Vaccine Initiative (IAVI) UKZNRSA1001, IIR AWARDNIMH NIH HHS R25 MH123256Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE)Wellcome Trust 223065Wellcome Trust (WT) 226405/Z/22/Z, 108079, 223065
6 · The paper itself

Abstract

High replicative capacity (RC) HIV-1 strains are associated with elevated viral loads and faster disease progression in the absence of antiretroviral therapy. Understanding the mechanisms by which high RC strains adversely affect the host is essential for developing novel anti-HIV interventions. This study investigates cellular metabolism, cytokine induction, and cell-to-cell spread as potential mechanisms differentiating clinical outcomes between low and high RC strains of HIV-1. We constructed chimeric viruses containing patient-derived

Indexed as

Cytokinesgag Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHIV ProteaseT-LymphocytesVirus ReplicationCell LineHumansViral LoadCytokinesgag Gene Products, Human Immunodeficiency VirusHIV Proteasep16 protease, Human immunodeficiency virus 1cell-to-cell spreadGagHIVinflammationmetabolismreplicative capacitysubtypesT-cell

Identifiers

PMID39998252
PMCPMC11980368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.