Evidence map›Paper›PMID 39998224›Full record

ArticlemBio2025

Natural compounds target the M23B zinc metallopeptidase Mpg to modulate

Kathleen R Nicholson, Shaohui Yin, Jennifer L Edwards, Chi-Hao Luan, H Steven Seifert

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kathleen R Nicholson *Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0002-6152-0259
Shaohui Yin *Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Jennifer L EdwardsCenter for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0003-3568-0344
Chi-Hao LuanHigh Throughput Analysis Laboratory and Department of Molecular Biosciences, Northwestern University, Evanston, USA.
H Steven SeifertDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID 0000-0001-8651-0375

Funding

Mechanisms of Gonococcal Pilin Antigenic/Phase VariationR37AI033493 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hank S. SEIFERT · 2003 to 2026
$10.1M
TRAINING PROGRAM IN IMMUNOLOGY &MOLECULAR PATHOGENESIST32AI007476 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Edward Benjamin Thorp · 1996 to 2026
$6.6M
Targeting the functions of the gonococcal Type lV pilusR01AI146073 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hank S. SEIFERT · 2020 to 2026
$3.3M
NIAID NIH HHS R01 AI146073NIAID NIH HHS R37 AI033493NIAID NIH HHS T32 AI007476
6 · The paper itself

Abstract

IMPORTANCE:

Indexed as

Anti-Bacterial AgentsBacterial ProteinsEnzyme InhibitorsFimbriae, BacterialMetalloproteasesNeisseria gonorrhoeaeGene Expression Regulation, BacterialHumansHydrolyzable TanninsAnti-Bacterial AgentsBacterial ProteinsEnzyme InhibitorsHydrolyzable TanninsMetalloproteasespunicalaginmetallopeptidasenatural compoundsNeisseria gonorrhoeaepilussmall molecule screen

Identifiers

PMID39998224
PMCPMC11980366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.