Evidence map›Paper›PMID 39998216›Full record

ArticlemBio2025

CsrA-mediated regulation of a virulence switch in

Raja Singh, María Pérez-Varela, Jennifer M Colquhoun, Carsten Kröger, Fergal J Hamrock, Ali Shaibah, Ellen L Neidle, Philip N Rather

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Loss of CsrA inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Swarm-seq Reveals Functional Divergence in CsrA Homologs Across Bacteria.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raja SinghDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
María Pérez-VarelaDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-0990-4041
Jennifer M ColquhounDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
Carsten KrögerDepartment of Microbiology, School of Genetics & Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0003-0461-1530
Fergal J HamrockDepartment of Microbiology, School of Genetics & Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland.
Ali ShaibahDepartment of Microbiology, School of Genetics & Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland.
Ellen L NeidleDepartment of Microbiology, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-1665-5303
Philip N RatherDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0001-9674-6250

Funding

CsrA mediated regulation of a virulence switch in Acinetobacter baumanniiR21AI180913 · NIAID · EMORY UNIVERSITY · PI RATHER, PHILIP N. · 2024 to 2025
$353k
BLRD VA I01 BX001725BLRD VA IK6 BX004470NIAID NIH HHS R21 AI180913
6 · The paper itself

Abstract

CsrA is an RNA binding protein that functions as a global regulator in bacteria. We demonstrate that, in IMPORTANCE: The World Health Organization has ranked

Indexed as

Acinetobacter baumanniiBacterial ProteinsGene Expression Regulation, BacterialRNA-Binding ProteinsProtein BindingRNA, BacterialRNA, Small UntranslatedVirulenceBacterial ProteinsRNA, BacterialRNA-Binding ProteinsRNA, Small UntranslatedAcinetobacter baumanniiCsrAphenotypic heterogeneitysmall RNAs

Identifiers

PMID39998216
PMCPMC11980544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.