Evidence map›Paper›PMID 39998112›Full record

ArticleToxins2025

Insights into the Role of Proteolytic and Adhesive Domains of Snake Venom Metalloproteinases from

Samuel C Teixeira, Thales A M Fernandes, Guilherme de Souza, Luana C Luz, Marina Paschoalino, Joed P de L Junior, Alessandra M Rosini, Aryani F F Martínez, Vitor de Freitas, Daiana S Lopes and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Novel drug candidates targetingFrontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Samuel C TeixeiraLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Thales A M FernandesLaboratory of Applied Toxinology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Guilherme de SouzaLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Luana C LuzLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Marina PaschoalinoLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Joed P de L JuniorLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Alessandra M RosiniLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Aryani F F MartínezLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Vitor de FreitasLaboratory of Biochemistry and Animal Toxins, Institute of Biotechnology, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Daiana S LopesInstitute Multidisciplinary in Health, Universidade Federal da Bahia (UFBA), Vitória da Conquista 45029-094, BA, Brazil.ORCID 0000-0002-2462-4163
Patrícia B ClissaLaboratory of Immunopathology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Vinícius C de SouzaLaboratory of Applied Toxinology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Milton Y Nishiyama-JrLaboratory of Applied Toxinology, Butantan Institute, São Paulo 05503-900, SP, Brazil.ORCID 0000-0002-2410-0562
Bellisa F BarbosaLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.
Eloisa A V FerroLaboratory of Immunophysiology of Reproduction, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.ORCID 0000-0002-7447-2583
Veridiana de M R ÁvilaLaboratory of Biochemistry and Animal Toxins, Institute of Biotechnology, Universidade Federal de Uberlândia, Uberlândia 38405-318, MG, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmosis is an alarming public health problem that affects more than one-third of the world's population. In our work, we investigated the antiparasitic effects of catalytically active [BpMP-I and Jararhagin (Jar)] and catalytically inactive [Jararhagin-C (Jar-C)] snake venom metalloproteinases (SVMPs) in human HeLa cells. These toxins impaired the parasite invasion and intracellular growth, and modulated IL-6, IL-8, and MIF cytokines that control the cell susceptibility and response against

Indexed as

Antiprotozoal AgentsBothropsCrotalid VenomsMetalloproteasesToxoplasmaToxoplasmosisAnimalsCytokinesHeLa CellsHumansProtein DomainsProteolysisAntiprotozoal AgentsCrotalid VenomsCytokinesMetalloproteasessnake venom metalloproteinasesToxoplasma gondiitoxoplasmosis

Identifiers

PMID39998112
PMCPMC11861417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.