Evidence map›Paper›PMID 39998096›Full record

ReviewToxins2025

Fifty Years of Aflatoxin Research in Qidong, China: A Celebration of Team Science to Improve Public Health.

Jian-Guo Chen, Yuan-Rong Zhu, Geng-Sun Qian, Jin-Bing Wang, Jian-Hua Lu, Thomas W Kensler, Lisa P Jacobson, Alvaro Muñoz, John D Groopman

Abstract readReviewHistorical Article
In one paragraph

Review in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Environmental risk factors for liver cancer.Hepatology (Baltimore, Md.) · 2025
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jian-Guo ChenDepartment of Epidemiology, Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong 226200, China.ORCID 0000-0003-4102-8934
Yuan-Rong ZhuDepartment of Epidemiology, Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong 226200, China.
Geng-Sun QianShanghai Cancer Institute, Shanghai Jiaotong University, Shanghai 200032, China.
Jin-Bing WangDepartment of Epidemiology, Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong 226200, China.
Jian-Hua LuDepartment of Epidemiology, Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong 226200, China.
Thomas W KenslerDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-6676-261X
Lisa P JacobsonDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0003-1722-6826
Alvaro MuñozDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
John D GroopmanDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Qidong Liver Cancer Institute (QDLCI) and the Qidong Cancer Registry were established in 1972 with input from doctors, other medical practitioners, and non-medical investigators arriving from urban centers such as Shanghai and Nanjing. Medical teams were established to quantify the extent of primary liver cancer in Qidong, a corn-growing peninsula on the north side of the Yangtze River. High rates of liver cancer were documented and linked to several etiologic agents, including aflatoxins. Local corn, the primary dietary staple, was found to be consistently contaminated with high levels of aflatoxins, and bioassays using this corn established its carcinogenicity in ducks and rats. Observational studies noted a positive association between levels of aflatoxin in corn and incidence of liver cancer across townships. Biomarker studies measuring aflatoxin B

Indexed as

AflatoxinsLiver NeoplasmsPublic HealthAnimalsChinaFood ContaminationHistory, 20th CenturyHistory, 21st CenturyHumansZea maysAflatoxinsaflatoxin-albumin adductaflatoxin B1aflatoxin-N7-guaninebroccoli sproutschemopreventionchlorophyllinclinical trialsliver canceroltiprazsulforaphane

Identifiers

PMID39998096
PMCPMC11860843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.